Reactome | NGEF exchanges GTP for GDP on RHOA

NGEF exchanges GTP for GDP on RHOA

Stable Identifier

R-HSA-3928651

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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The tyrosine phosphorylation of ephexin1 (NGEF)/Ephexin-1 enhances its exchange activity and specifically activates inactive RHOA:GDP to active RHOA:GTP. Activated RHOA regulates myosin II activity in neurons through Rho-associated kinase (ROCK), and leads to rapid growth cone collapse, neurite retraction, or neurite growth inhibition in axons. Through this repulsive mechanism EPH receptors and ephrins (EFNs) guide retinal axons to their targets in the visual centres in the brain (Sahin et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15848799	Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse Debant, A, Greenberg, ME, Corfas, G, Lin, MZ, Wright, TM, Schmidt, S, Cowan, CW, Krull, CE, Sahin, M, Hu, L, Shamah, SM, Goldberg, JL, Poucher, H, Greer, PL, O'connell, S, Eberhart, J	Neuron	2005
10769020	Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase Aktories, K, Ciossek, T, Wahl, S, Mueller, BK, Barth, H	J. Cell Biol.	2000
11179879	Rho GTPases in growth cone guidance Dickson, BJ	Curr. Opin. Neurobiol.	2001