Reactome | WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling

WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling

Stable Identifier

R-HSA-3965446

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of a number of 'non-canonical' WNT ligands, notably WNT5a and WNT11, to select FZD receptors has been shown to activate PLC and stimulate release of intracellular calcium stores (reviewed in De, 2011; Kuhl et al, 2000b). This WNT/Ca2+ pathway, which was first demonstrated in zebrafish and has subsequently been identified in Xenopus and human cells as well, activates CaMKII, PKC and calcineurin signaling (Slusarski et al, 1997a, b; Kuhl et al, 2000a, b; reviewed in Angers and Moon, 2009; Niehrs, 2012).

Literature References

PubMed ID	Title	Journal	Year
19536106	Proximal events in Wnt signal transduction Angers, S, Moon, RT	Nat Rev Mol Cell Biol	2009
9389482	Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling Corces, VG, Slusarski, DC, Moon, RT	Nature	1997
21903638	Wnt/Ca2+ signaling pathway: a brief overview De, A	Acta Biochim. Biophys. Sin. (Shanghai)	2011
10858654	The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape Sheldahl, LC, Kühl, M, Moon, RT, Miller, JR, Park, M	Trends Genet.	2000
9073455	Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A Yang-Snyder, J, Busa, WB, Moon, RT, Slusarski, DC	Dev. Biol.	1997
23151663	The complex world of WNT receptor signalling Niehrs, C	Nat. Rev. Mol. Cell Biol.	2012