G-protein subunits dissociate from WNT:FZD complex

Stable Identifier
R-HSA-3965447
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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After nucleotide exchange, the G-protein alpha subunit dissociates from the beta-gamma complex (reviewed in Malbon, 2004). The G-alpha t2 and o subunits activate signaling through PDEs and promote the release of intracellular calcium (Ahumada et al, 2002; reviewed in Wang and Malbon, 2004) while the beta-gamma complex recruits PLC and initiates phosphoinositol signaling (reviewed in Smrcka, 2008), although both components may also play other roles.
Literature References
PubMed ID Title Journal Year
12471263 Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP

Wang, HY, Liu, X, Slusarski, DC, Malbon, CC, Ahumada, A, Moon, RT

Science 2002
18488142 G protein betagamma subunits: central mediators of G protein-coupled receptor signaling

Smrcka, AV

Cell Mol Life Sci 2008
14704854 Wnt-frizzled signaling to G-protein-coupled effectors

Wang, H, Malbon, CC

Cell. Mol. Life Sci. 2004
14977528 Frizzleds: new members of the superfamily of G-protein-coupled receptors

Malbon, CC

Front. Biosci. 2004
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