Reactome | UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1

UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1

Stable Identifier

R-HSA-3968414

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1

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UBC9 and PIAS1 SUMOylate FOXL2 with SUMO1 (Kuo et al. 2009, Marongiu et al 2010, Georges et al. 2011). This modification changes its cellular localization, stability and transcriptional activity (Marongiu et al, 2010). SUMOylation localizes FOXL2 to PML bodies in the nucleus. SUMOylation is required for repression of transcription by FOXL2 at the StAR promoter and reduces transactivation by FOXL2 at the PER2 promoter. Hypophosphorylation of serine-33 correlates with SUMOylation and stablization of FOXL2, leading to enhanced transcriptional activation of TNF-R1, FAS, caspase 8, p21, and aromatase (Kim et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
20209145	The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity Marongiu, M, Deiana, M, Meloni, A, Marcia, L, Puddu, A, Cao, A, Schlessinger, D, Crisponi, L	PLoS ONE	2010
19744555	Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene Kuo, FT, Bentsi-Barnes, IK, Barlow, GM, Bae, J, Pisarska, MD	Cell. Signal.	2009
24390485	FOXL2 posttranslational modifications mediated by GSK3β determine the growth of granulosa cell tumours Kim, JH, Kim, YH, Kim, HM, Park, HO, Ha, NC, Kim, TH, Park, M, Lee, K, Bae, J	Nat Commun	2014
22022399	SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies Georges, A, Benayoun, BA, Marongiu, M, Dipietromaria, A, L'Hôte, D, Todeschini, AL, Auer, J, Crisponi, L, Veitia, RA	PLoS ONE	2011