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FES [cytosol]
Stable Identifier
R-HSA-396937
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Proto-oncogene tyrosine-protein kinase Fes/Fps , FES_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P15924 DSP
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
CRMPs in Sema3A signaling (Homo sapiens)
Tyrosine phosphorylation of CRMPs by Fes (Homo sapiens)
FES [cytosol] (Homo sapiens)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
Phosphorylation of Plexin-A (Homo sapiens)
FES [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07332 FES
Gene Names
FES, FPS
Chain
chain:1-822
Reference Genes
BioGPS Gene:2242 FES
COSMIC (genes):FES FES
CTD Gene:2242 FES
dbSNP Gene:2242 FES
ENSEMBL:ENSG00000182511 FES
HGNC:3657 FES
KEGG:hsa:2242 FES
Monarch:2242 FES
NCBI Gene:2242 FES
OMIM:190030 FES
UCSC:P07332 FES
Reference Transcript
RefSeq:XM_054377497.1 FES
RefSeq:XM_054377500.1 FES
RefSeq:XM_054377501.1 FES
RefSeq:XM_054377504.1 FES
RefSeq:XM_054377503.1 FES
RefSeq:XM_054377507.1 FES
RefSeq:XM_047432237.1 FES
RefSeq:XM_054377495.1 FES
RefSeq:XM_017022009.3 FES
RefSeq:XM_054377496.1 FES
RefSeq:XM_047432233.1 FES
RefSeq:NM_001143784.1 FES
RefSeq:NM_002005.4 FES
RefSeq:XM_017022007.2 FES
RefSeq:XM_017022008.2 FES
RefSeq:XM_017022010.2 FES
RefSeq:XM_047432235.1 FES
RefSeq:XM_017022005.2 FES
RefSeq:XM_054377505.1 FES
RefSeq:XM_005254880.2 FES
RefSeq:XM_005254882.3 FES
RefSeq:XM_054377502.1 FES
RefSeq:XM_017022006.2 FES
RefSeq:XM_047432234.1 FES
RefSeq:NM_001143783.1 FES
RefSeq:NM_001143785.2 FES
RefSeq:XM_054377498.1 FES
RefSeq:XM_054377499.1 FES
Other Identifiers
11722038_a_at
11722039_x_at
11740874_a_at
16804964
1976_s_at
205418_PM_at
205418_at
2242
3608426
3608428
3608429
3608430
3608431
3608432
3608433
3608434
3608435
3608436
3608437
3608438
3608439
3608440
3608441
3608442
3608443
3608444
3608445
3608446
3608447
3608448
3608449
3608450
3608451
3608452
3608453
3608454
3608455
3608456
3608457
3608458
3608459
3608460
3608461
3608462
3608463
7986110
A_14_P105951
A_23_P14769
GE59770
GO:0000166
GO:0001578
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005737
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006468
GO:0006935
GO:0007010
GO:0007098
GO:0007155
GO:0008017
GO:0008092
GO:0008289
GO:0008360
GO:0009898
GO:0010976
GO:0015630
GO:0016020
GO:0016301
GO:0016740
GO:0018108
GO:0030155
GO:0031116
GO:0031410
GO:0032273
GO:0034987
GO:0035091
GO:0042127
GO:0043304
GO:0045595
GO:0045639
GO:0045657
GO:0046777
GO:0051450
GO:0051495
GO:0060038
GO:0060627
GO:0070161
GO:0071305
GO:0120035
GO:0140096
GO:1902905
GO:2000145
HMNXSV003039920
HMNXSV003044001
HMNXSV003053220
ILMN_1693650
PH_hs_0000788
TC15000871.hg
X52192_at
g13376997_3p_at
Participates
as a member of
Tyrosine kinases [cytosol] (Homo sapiens)
as an input of
Phosphorylation of Plexin-A (Homo sapiens)
as a component of
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Inferred To
FES [cytosol]
(Bos taurus)
FES [cytosol]
(Canis familiaris)
FES [cytosol]
(Gallus gallus)
FES [cytosol]
(Sus scrofa)
FER [cytosol]
(Drosophila melanogaster)
Ghost homologue of FES [cytosol]
(Danio rerio)
fes [cytosol]
(Xenopus tropicalis)
Fes [cytosol]
(Mus musculus)
Fes [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_047288193.1
,
XP_047288190.1
,
XP_016877499.1
,
XP_016877495.1
,
XP_016877494.1
,
XP_047288191.1
,
XP_016877498.1
,
XP_054233473.1
,
XP_054233471.1
,
XP_054233479.1
,
XP_054233475.1
,
XP_054233477.1
,
XP_054233480.1
,
XP_054233482.1
,
XP_016877496.1
,
XP_016877497.1
,
NP_001996.1
,
XP_005254939.1
,
XP_005254937.1
,
XP_047288189.1
,
XP_054233470.1
,
XP_054233474.1
,
XP_054233472.1
,
XP_054233478.1
,
XP_054233476.1
,
NP_001137256.1
,
NP_001137255.1
,
NP_001137257.1
ZINC - World Drugs
FES_HUMAN
Guide to Pharmacology - Targets
2023
OpenTargets
ENSG00000182511
ENSEMBL
ENSP00000414629
,
ENSP00000400868
,
ENST00000414248
,
ENSP00000377837
,
ENST00000328850
,
ENST00000444422
,
ENSG00000182511
,
ENSP00000331504
,
ENST00000394300
ZINC - FDA approved
FES_HUMAN
ZINC - Substances
FES_HUMAN
ZINC - Biogenic
FES_HUMAN
ZINC target
P07332
PRO
P07332
PDB
3CBL
,
8XKP
,
4DYL
,
2DCR
,
1WQU
,
3CD3
,
8X2T
,
3BKB
,
6JMF
,
7T1L
,
4E93
,
7T1K
ZINC - Investigational
FES_HUMAN
HPA
ENSG00000182511-FES
GeneCards
FES
Pharos - Targets
P07332
ZINC - Predictions - Purchasable
FES_HUMAN
HMDB Protein
HMDBP01494
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15311 EZR
3
p-Y146,Y354-EZR [cytosol]
(R-HSA-374572)
p-T567-EZR [cytosol]
(R-HSA-374559)
EZR [cytosol]
(R-HSA-9020826)
0.678
8
UniProt:P15924 DSP
4
DSP [cornified envelope]
(R-HSA-8847736)
DSP [ficolin-1-rich granule membrane]
(R-HSA-6801396)
DSP(?-?) [plasma membrane]
(R-HSA-351843)
DSP [plasma membrane]
(R-HSA-201580)
0.564
2
UniProt:P54274 TERF1
1
TERF1 [nucleoplasm]
(R-HSA-164618)
0.508
2
UniProt:Q99750 MDFI
0.488
2
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