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RND1 [plasma membrane]
Stable Identifier
R-HSA-396949
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Rho-related GTP-binding protein Rho6 (Rnd1) , RND1_HUMAN, RHO6
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1 [plasma membrane] (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
Recruitment of Rnd1 to Plexin A (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1 [plasma membrane] (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
LARG and PDZ-RhoGEF binds to Plexin-B1 (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
Sema4D mediated inhibition of cell attachment and migration (Homo sapiens)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
Rnd1 interacts with Plexin-B1:Sema4D (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
p190RhoGAP binds Plexin-B1 (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RND1 GTPase cycle (Homo sapiens)
RND1 binds GTP (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
RND1 binds effectors (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
RND1:GTP:RND1 effectors [plasma membrane] (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
RND1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92730 RND1
Gene Names
RND1, RHO6
Chain
chain:1-229, propeptide:230-232
Reference Genes
BioGPS Gene:27289 RND1
COSMIC (genes):RND1 RND1
CTD Gene:27289 RND1
dbSNP Gene:27289 RND1
ENSEMBL:ENSG00000172602 RND1
HGNC:18314 RND1
KEGG:hsa:27289 RND1
Monarch:27289 RND1
NCBI Gene:27289 RND1
OMIM:609038 RND1
UCSC:Q92730 RND1
Reference Transcript
RefSeq:NM_014470.3 RND1
Other Identifiers
11732233_a_at
11732234_a_at
16764053
210056_PM_at
210056_at
27289
3453349
3453350
3453351
3453352
3453353
3453354
3453355
3453356
3453359
3453360
3453361
3453362
37785_at
7962884
A_23_P53370
GE62482
GO:0003824
GO:0003924
GO:0005102
GO:0005515
GO:0005525
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005912
GO:0007015
GO:0007162
GO:0007165
GO:0007264
GO:0015629
GO:0016322
GO:0016477
GO:0016787
GO:0019901
GO:0032956
GO:0043226
GO:0043231
GO:0048870
HMNXSV003016407
Hs.124940.0.S2_3p_at
ILMN_1651838
PH_hs_0007040
TC12001459.hg
Participates
as an input of
RND1 binds GTP (Homo sapiens)
as a component of
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
RND1:GTP [plasma membrane] (Homo sapiens)
Inferred To
Homologues of RND1 [plasma membrane]
(Saccharomyces cerevisiae)
Homologues of RND1 [plasma membrane]
(Schizosaccharomyces pombe)
Rnd1 [plasma membrane]
(Rattus norvegicus)
RND1 [plasma membrane]
(Bos taurus)
RND1 [plasma membrane]
(Canis familiaris)
RND1 [plasma membrane]
(Gallus gallus)
RND1 [plasma membrane]
(Mus musculus)
RND1 [plasma membrane]
(Saccharomyces cerevisiae)
RND1 [plasma membrane]
(Schizosaccharomyces pombe)
RND1 [plasma membrane]
(Sus scrofa)
rnd1 [plasma membrane]
(Xenopus tropicalis)
Ghost homologue of RND1 [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of RND1 [plasma membrane]
(Drosophila melanogaster)
rnd1b [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_055285.1
ENSEMBL
ENSP00000308461
,
ENST00000309739
OpenTargets
ENSG00000172602
HPA
ENSG00000172602-RND1
PRO
Q92730
Pharos - Targets
Q92730
HMDB Protein
HMDBP02857
PDB
3Q3J
,
2REX
,
2CLS
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43157 PLXNB1
2
p-Y-PLXNB1 [plasma membrane]
(R-HSA-419609)
PLXNB1 [plasma membrane]
(R-HSA-3008951)
0.775
5
UniProt:Q14451 GRB7
1
GRB7 [cytosol]
(R-HSA-204819)
0.581
4
UniProt:O15031 PLXB2
0.558
2
UniProt:Q8TED1 GPX8
1
GPX8 [endoplasmic reticulum lumen]
(R-HSA-3341303)
0.556
3
UniProt:P53365 ARFIP2
1
ARFIP2 [cytosol]
(R-HSA-6813848)
0.556
3
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