Thrombin-activated PAR binds G-protein Gq

Stable Identifier
R-HSA-396996
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Thrombin signalling through PARs is mediated in part through the Gq family of G-proteins. Gq knockout mice have defective platelet responses to thrombin (as well as to ADP and thromboxane).

Literature References
PubMed ID Title Journal Year
8982657 Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells

Ogino, Y, Tanaka, K, Shimizu, N

Eur J Pharmacol 1996
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Participant Of
Orthologous Events
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