G-protein beta:gamma signalling

Stable Identifier
R-HSA-397795
Type
Pathway
Species
Homo sapiens
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5/5
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The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha.
Literature References
PubMed ID Title Journal Year
18834311 The Role of Gbetagamma Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes

Robitaille, M, Dupré, DJ, Rebois, RV, Hébert, TE

Annu Rev Pharmacol Toxicol 2008
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