G-protein alpha (12/13):LARG [plasma membrane]

Stable Identifier
R-HSA-398145
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
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General
Phospholipase C activation is the classical signalling route for G alpha (q) but an additional mechanism is an inhibitory interaction between G alpha (q) and phosphatidylinositol 3-kinase alpha (PI3K alpha). There are several PI3K subtypes but only the p85 alpha/p110 alpha subtype (PI3K alpha) is a G alpha (q) effector (PMID: 18515384). Activated G alpha (q) inhibits PI3K alpha directly, in a GTP-dependent manner. G alpha(q) binding of PI3K competes with Ras, a PI3K activator (PMID: 16268778).
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Inferred To
G-protein alpha (12/13):LARG [plasma membrane] (Bos taurus)
G-protein alpha (12/13):LARG [plasma membrane] (Caenorhabditis elegans)
G-protein alpha (12/13):LARG [plasma membrane] (Canis familiaris)
G-protein alpha (12/13):LARG [plasma membrane] (Drosophila melanogaster)
G-protein alpha (12/13):LARG [plasma membrane] (Gallus gallus)
G-protein alpha (12/13):LARG [plasma membrane] (Mus musculus)
G-protein alpha (12/13):LARG [plasma membrane] (Rattus norvegicus)
G-protein alpha (12/13):LARG [plasma membrane] (Sus scrofa)
G-protein alpha (12/13):LARG [plasma membrane] (Xenopus tropicalis)
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