LARG activation by G alpha 12/13

Stable Identifier
R-HSA-398184
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Leukemia-associated RhoGEF (LARG) serves as a G alpha responsive RhoGEF for G alpha 12, 13 and possibly G alpha q. G alpha 12 activity appears to depend on LARG tyrosine phosphorylation by Tec-family kinases (Suzuki et al. 2003) or FAK (Chikumi et al. 2002). The involvement of LARG may be specific to particular receptor signalling pathways; RNAi-mediated knockdown of LARG specifically inhibited thrombin signaling via PAR1 but not LPA receptors (Wang et al 2004).

Literature References
PubMed ID Title Journal Year
12515866 Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF Proc Natl Acad Sci U S A 2003
Participants
Participant Of
Orthologous Events