Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
LARG binds plexin B1
Stable Identifier
R-HSA-398185
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
LARG binds plexin B1 (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
LARG binds plexin-B1, a transmembrane receptor for the semaphorin Sema4D. Binding of Sema4D to plexin-B1 stimulates RhoA activation.
Literature References
PubMed ID
Title
Journal
Year
12123608
Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology
Offermanns, S
,
Behrens, J
,
Kuner, R
,
Swiercz, JM
Neuron
2002
Participants
Input
G-protein alpha (12/13):LARG [plasma membrane]
(Homo sapiens)
PLXNB1 [plasma membrane]
(Homo sapiens)
Output
G-protein alpha (12/13):LARG:Plexin B1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
G alpha (12/13) signalling events (Homo sapiens)
Orthologous Events
LARG binds plexin B1 (Bos taurus)
LARG binds plexin B1 (Caenorhabditis elegans)
LARG binds plexin B1 (Canis familiaris)
LARG binds plexin B1 (Drosophila melanogaster)
LARG binds plexin B1 (Gallus gallus)
LARG binds plexin B1 (Mus musculus)
LARG binds plexin B1 (Rattus norvegicus)
LARG binds plexin B1 (Sus scrofa)
LARG binds plexin B1 (Xenopus tropicalis)
Authored
Jupe, S (2009-03-18)
Reviewed
Akkerman, JW (2009-06-03)
Created
Jupe, S (2009-03-18)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text