Reactome | p-S3-CFL1 [cytosol]

p-S3-CFL1 [cytosol]

Stable Identifier

R-HSA-399813

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

pCofilin-1(S3)

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - Phosphorylation of cofilin by LIMK-1 (Homo sapiens)
        
        pCofilin: Active LIMK-1 [cytosol] (Homo sapiens)
        
        p-S3-CFL1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23528 CFL1

Gene Names

CFL1, Cofilin-1, CFL

Chain

initiator methionine:, chain:2-166

Reference Genes

BioGPS Gene:1072 CFL1

COSMIC (genes):CFL1 CFL1

CTD Gene:1072 CFL1

dbSNP Gene:1072 CFL1

ENSEMBL:ENSG00000172757 CFL1

ENSEMBL_homo_sapiens_GENE:ENSG00000172757.13 CFL1

HGNC:1874 CFL1

KEGG Gene (Homo sapiens):1072 CFL1

Monarch:1072 CFL1

NCBI Gene:1072 CFL1

OMIM:601442 CFL1

Reference Transcript

RefSeq:NM_005507.2 CFL1

Other Identifiers

1072

11753645_a_at

11753646_x_at

11754158_a_at

11757818_x_at

11763259_x_at

1555730_PM_a_at

1555730_a_at

16654211

16654213

16654215

16654217

16654233

16654235

16654237

16654239

16654241

16654243

18671394

18671395

18671397

18671403

18671404

18671405

200021_PM_at

200021_at

33659_at

3377891

3377892

3377893

3377894

3377895

3377897

3377899

3377902

75185_f_at

7892701

7894264

7895149

7895299

7895945

7896038

7949496

GE79937

GO:0000278

GO:0000281

GO:0000910

GO:0003779

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0007010

GO:0007266

GO:0008092

GO:0009615

GO:0012501

GO:0015629

GO:0016020

GO:0016363

GO:0022604

GO:0023052

GO:0030027

GO:0030036

GO:0030042

GO:0030043

GO:0030154

GO:0030424

GO:0030426

GO:0031258

GO:0031982

GO:0032587

GO:0034330

GO:0040019

GO:0042995

GO:0043066

GO:0043226

GO:0044794

GO:0048856

GO:0051014

GO:0051015

GO:0051293

GO:0061001

GO:0070062

HMNXSV003014976

Hs2.180370.2.S1_3p_s_at

ILMN_1705617

TC11001945.hg

X95404_at

g5031634_3p_at

g5031634_3p_x_at

Participates

as an output of

LIMK phosphorylates CFL1, inactivating it (Homo sapiens)

as a component of

pCofilin: Active LIMK-1 [cytosol] (Homo sapiens)

Other forms of this molecule

CFL1 [cytosol]

CFL1 [extracellular region]

Modified Residues

Name

O-phospho-L-serine at 3

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_005498.1

OpenTargets

ENSG00000172757

GeneCards

P23528

HPA

ENSG00000172757-CFL1

Ensembl

ENSP00000309629, ENSG00000172757, ENST00000525451, ENST00000308162, ENSP00000432660

PRO

P23528

Pharos - Targets

P23528

PDB

6UC4, 5HVK, 1Q8G, 4BEX, 6UBY, 1Q8X, 6VAO, 5L6W, 3J0S, 6UC0

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB [nucleoplasm] (R-HSA-3321990) ACTB [cytosol] (R-HSA-201861) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [plasma membrane] (R-HSA-196016)	0.933	11
UniProt:P63261 ACTG1	3	ACTG1 [cytosol] (R-HSA-201858) ACTG1 [lysosomal membrane] (R-HSA-196169) ACTG1 [plasma membrane] (R-HSA-196044)	0.831	10
UniProt:P53667 LIMK1	3	p-S,T508-LIMK1 [cytosol] (R-HSA-419610) p-T508-LIMK1 [cytosol] (R-HSA-399816) LIMK1 [cytosol] (R-HSA-397785)	0.722	3
UniProt:P54253 ATX1			0.703	11
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.668	3
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.656	3
UniProt:P40123 CAP2	1	CAP2 [cytosol] (R-HSA-428863)	0.643	4
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.577	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.577	3
UniProt:Q13393 PLD1	4	PLD1 [endoplasmic reticulum membrane] (R-HSA-1498795) PLD1 [plasma membrane] (R-HSA-2028998) PLD1 [tertiary granule membrane] (R-HSA-6800955) PLD1 [specific granule membrane] (R-HSA-6799531)	0.571	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	10
UniProt:P68032 ACTC1	1	ACTC1 [cytosol] (R-HSA-390536)	0.564	2
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.556	3
UniProt:Q549N0 Q549N0			0.556	3
UniProt:Q1KLZ0 Q1KLZ0			0.556	3
UniProt:Q15303 ERBB4			0.553	2
UniProt:Q9Y281 COF2			0.547	3
UniProt:O14939 PLD2	2	PLD2 [plasma membrane] (R-HSA-2029075) PLD2 [endoplasmic reticulum membrane] (R-HSA-1498791)	0.544	2
UniProt:P57058 HUNK			0.524	2
UniProt:P0DOE7 M	5	p-S95,T205-M [cytosol] (R-RSY-9831678) p-S95,T205-M [nucleoplasm] (R-RSY-9831706) M [nucleoplasm] (R-RSY-9831711) Nascent M [cytosol] (R-RSY-9828672) p-S95,T205-M [viral tegument] (R-RSY-9836531)	0.524	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2

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