Sema3A binds Nrp-1 bound to PlexinA

Stable Identifier
R-HSA-399933
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Although neuropilin-1 is required for Sema-3A action, it is incapable of transmitting a Sema-3A signal to the growth cone interior. The function of Sema-3A is mediated by Plexins. Sema-3A binds with high affinity to Plexin when the latter is complexed with Neuropilin-1.
Plexin-A1 is known to act as an R-Ras GAP (GTPase activating protein) when bound by Sema-3A. Plexin's GAP activity is regulated by FARP2 mediated Rac1 activation. Sema-3A binding to neuropilin-1/Plexin-A1 seems to induce a conformational change of plexin-A1 necessary for releasing FARP2. This suggests that neuropilin1 is required not only for ligand binding, but also for signaling, by modulating the interaction of FARP2 with plexin-A1.

Literature References
PubMed ID Title Journal Year
10679438 Semaphorins and their receptors in vertebrates and invertebrates

Raper, JA

Curr Opin Neurobiol 2000
16286926 FARP2 triggers signals for Sema3A-mediated axonal repulsion

Toyofuku, T, Yoshida, J, Sugimoto, T, Zhang, H, Kumanogoh, A, Hori, M, Kikutani, H

Nat Neurosci 2005
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