Inhibition of integrin activation by sequestering PIP5KIgamma

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R-HSA-399936
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Reaction [transition]
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Homo sapiens
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Sema3A also mediates integrin inhibition by a mechanism involving PIPKI gamma 661, a phosphatidylinositol kinase that participates in integrin mediated focal adhesion assembly. The binding of talin to beta-integrin is required for integrin activation and is strengthened by PtdIns(4,5)P(2). PIPKI gamma 661, an enzyme that makes PtdIns(4,5)P(2), is targeted to focal adhesions by an association with talin. Sema3A induced dissociation of FARP2 from Plexin-A1 stimulates an interaction between FARP2 and PIPKI gamma 661. FARP2 inhibits PIPK gamma 661's kinase activity, and thus inhibits integrin mediated adhesion.

Literature References
PubMed ID Title Journal Year
10934324 Molecular basis of semaphorin-mediated axon guidance

Nakamura, F, Kalb, RG, Strittmatter, SM

J Neurobiol 2000
12422220 Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions

Ling, K, Doughman, RL, Firestone, AJ, Bunce, MW, Anderson, RA

Nature 2002
16286926 FARP2 triggers signals for Sema3A-mediated axonal repulsion

Toyofuku, T, Yoshida, J, Sugimoto, T, Zhang, H, Kumanogoh, A, Hori, M, Kikutani, H

Nat Neurosci 2005
16930978 Repulsion or adhesion: receptors make the call

Halloran, MC, Wolman, MA

Curr Opin Cell Biol 2006
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