Activation of Rac1 by FARP2

Stable Identifier
R-HSA-399938
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Sema3A-mediated dissociation of FARP2 from Plexin-A is followed by activation of Rac1 by the GEF activity of released FARP2.
FARP2 is critical for Sema3A-mediated axonal repulsion through two independent downstream signaling pathways. Sema3A mediated disassociation of FARP2 from Plexin-A is followed by activation of Rac by GEF activity of released FARP2, binding of Rnd1 to plexin-A and down regulation of R-Ras by GAP activity of plexin-A.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Rac guanyl-nucleotide exchange factor activity of FARP2 [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created