Plexin-A1-4 binds NRP1

Stable Identifier
R-HSA-399942
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Plexin-A1-4 binds NRP1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The best characterized receptors for mediating semaphorin signaling are members of the neuropilin and plexin families of transmembrane proteins. Neuropilins form complexes with Plexin-A which in turn can act as a signaling moiety. Also, when complexed with neuropilin-1, plexin-A1 can associate directly with the FERM domain containing guanine nucleotide exchange factor (GEF) FARP2. FARP2 exerts GEF activity for Rac but not Cdc42 and Rho.
Participants
Input
Output
Participates
as an event of
Inferred From
Plexin-A binds to neuropilin-1 (Mus musculus)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kikutani, H  (2009-09-02)
Kumanogoh, A  (2009-09-02)
Created
Garapati, P V  (2009-03-23)
Cite Us!