Sema3A PAK dependent Axon repulsion

Stable Identifier
R-HSA-399954
Type
Pathway
Species
Homo sapiens
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Activated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin.

Literature References
PubMed ID Title Journal Year
11604131 Plexin signaling via off-track and rho family GTPases

Whitford, KL, Ghosh, A

Neuron 2001
11276226 Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse

Aizawa, H, Wakatsuki, S, Ishii, A, Moriyama, K, Sasaki, Y, Ohashi, K, Sekine-Aizawa, Y, Sehara-Fujisawa, A, Mizuno, K, Goshima, Y, Yahara, I

Nat Neurosci 2001
18374575 Semaphorin signaling: progress made and promises ahead

Zhou, Y, Gunput, RA, Pasterkamp, RJ

Trends Biochem Sci 2008
12593985 Semaphorin junction: making tracks toward neural connectivity

Pasterkamp, RJ, Kolodkin, AL

Curr Opin Neurobiol 2003
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