SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Stable Identifier
R-HSA-399955
Type
Pathway
Species
Homo sapiens
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Sema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the signal-transducing subunit. Sema3A inhibits cell migration by inhibiting integrin ligand-binding activity.

Literature References
PubMed ID Title Journal Year
18580951 The semaphorins: versatile regulators of tumour progression and tumour angiogenesis

Neufeld, G, Kessler, O

Nat Rev Cancer 2008
16286926 FARP2 triggers signals for Sema3A-mediated axonal repulsion

Toyofuku, T, Yoshida, J, Sugimoto, T, Zhang, H, Kumanogoh, A, Hori, M, Kikutani, H

Nat Neurosci 2005
18374575 Semaphorin signaling: progress made and promises ahead

Zhou, Y, Gunput, RA, Pasterkamp, RJ

Trends Biochem Sci 2008
Participants
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Orthologous Events
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