Reactome | Gi,Go Heterotrimeric G-protein complex dissociates

Gi,Go Heterotrimeric G-protein complex dissociates

Stable Identifier

R-HSA-400037

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Gi,Go Heterotrimeric G-protein complex dissociates

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Exchange of GDP for GTP by the alpha subunit of the heterotrimeric G-protein complex causes the complex to dissociate into the G alpha:GTP complex and the beta-gamma complex. Both complexes have effector functions.

Literature References

PubMed ID	Title	Journal	Year
7641683	Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits Okamoto, T, Regazzi, R, Kiraly, C, Lang, J, Weller, U, Wollheim, CB, Nishimoto, I	EMBO J	1995
8997178	Mechanisms of inhibition of insulin release Sharp, GW	Am J Physiol	1996
14514350	Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice Chao, CM, Brede, M, Hein, L, Sieg, A, Peterhoff, M, Ullrich, S	Eur J Endocrinol	2003
17095603	Some G protein heterotrimers physically dissociate in living cells Lambert, NA, Digby, GJ, Sethi, PR, Lober, RM	Proc Natl Acad Sci U S A	2006
19258039	The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers Lambert, NA, Digby, GJ, Hollins, B, Kuravi, S	Cell Signal	2009
17900700	G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes Ahren, B, Winzell, MS	Pharmacol Ther	2007
16373322	GPCR-induced dissociation of G-protein subunits in early stage signal transduction Bucco, O, Aloia, AL, McMurchie, EJ, Leifert, WR	Mol Membr Biol	2005
18162464	Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel Straub, SG, Fang, Q, Sharp, GW, Zhao, Y	J Biol Chem	2008