PPARA:RXRA heterodimer recruits corepressors

Stable Identifier
R-HSA-400183
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In the absence of activating ligands of PPAR-alpha, the PPAR-alpha:RXR-alpha heterodimers recruit corepressors NCoR1, NCoR2(SMRT), and histone deacetylases (HDACs) to genes regulated by PPAR-alpha. The corepressors maintain chromatin at the gene in an inactive conformation and prevent expression of the gene.

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Orthologous Events
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