Reactome | PPARA [nucleoplasm]

PPARA [nucleoplasm]

Stable Identifier

R-HSA-400186

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Peroxisome proliferator-activated receptor alpha, PPAR-alpha

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Locations in the PathwayBrowser for interactor UniProt:P22607

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External Reference Information

External Reference

UniProt:Q07869 PPARA

Gene Names

PPARA, NR1C1, PPAR

Chain

chain:1-468

Reference Genes

BioGPS Gene:5465 PPARA

COSMIC (genes):PPARA PPARA

CTD Gene:5465 PPARA

dbSNP Gene:5465 PPARA

ENSEMBL:ENSG00000186951 PPARA

HGNC:9232 PPARA

KEGG Gene (Homo sapiens):5465 PPARA

Monarch:5465 PPARA

NCBI Gene:5465 PPARA

UCSC:Q07869 PPARA

Reference Transcript

Other Identifiers

0000540300

11724411_a_at

11724412_a_at

11724413_s_at

11758903_at

11763524_a_at

1556064_at

1558631_at

16931339

16931358

206870_at

223437_at

223438_s_at

226978_at

244689_at

3948959

3948962

3948974

3948980

3948981

3948983

3948986

3948987

3948992

3948994

3948995

3948996

3948997

3948998

3948999

3949000

3949001

3949002

3949003

3949010

47512_at

5465

59974_r_at

8073826

86444_at

90256_at

929_at

A_14_P133767

A_23_P211643

A_24_P417036

A_24_P570049

A_32_P198371

GE62555

GE83467

GE87082

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0001103

GO:0001223

GO:0001227

GO:0001228

GO:0001666

GO:0003013

GO:0003674

GO:0003677

GO:0003700

GO:0003707

GO:0004879

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005975

GO:0006091

GO:0006355

GO:0006367

GO:0006629

GO:0006631

GO:0006810

GO:0006950

GO:0007155

GO:0007165

GO:0007507

GO:0008134

GO:0008144

GO:0008150

GO:0008219

GO:0008270

GO:0008289

GO:0008544

GO:0009056

GO:0009058

GO:0009267

GO:0009755

GO:0010468

GO:0010565

GO:0010745

GO:0010876

GO:0010883

GO:0010887

GO:0010891

GO:0014070

GO:0019216

GO:0019217

GO:0019899

GO:0019902

GO:0019904

GO:0030154

GO:0030512

GO:0030522

GO:0031624

GO:0032000

GO:0032091

GO:0032099

GO:0032868

GO:0032922

GO:0033993

GO:0034641

GO:0035095

GO:0038023

GO:0040007

GO:0042060

GO:0042157

GO:0042752

GO:0043167

GO:0043226

GO:0043401

GO:0043565

GO:0044281

GO:0044403

GO:0044877

GO:0045070

GO:0045471

GO:0045722

GO:0045776

GO:0045820

GO:0045893

GO:0045923

GO:0045944

GO:0046321

GO:0046872

GO:0046889

GO:0048511

GO:0048646

GO:0048856

GO:0050728

GO:0051525

GO:0051898

GO:0061052

GO:0070166

GO:0097371

GO:1900016

GO:1901215

GO:1902894

GO:1903038

GO:1903427

GO:1903944

GO:2000191

GO:2000272

GO:2001171

HMNXSV003000005

HMNXSV003014939

Hs.272006.0.A1_3p_at

Hs.272006.0.A1_3p_x_at

Hs.275711.0.S2_3p_at

Hs.286014.0.S1_3p_at

Hs2.199700.1.A1_3p_at

Hs2.391179.1.A1_3p_at

ILMN_1659346

ILMN_2362847

L02932_at

PH_hs_0023352

PH_hs_0026238

PH_hs_0034827

PH_hs_0035085

TC22000392.hg

TC22001154.hg

TC22001155.hg

TC22001156.hg

g13278779_3p_a_at

g7549810_3p_at

Participates

as an input of

as a member of

NR [nucleoplasm] (Homo sapiens)

as an output of

Expression of PPARA (Homo sapiens)

as a component of

Other forms of this molecule

SUMO1-K185-PPARA [nucleoplasm]

Inferred To

nhr-2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of PPARA [nucleoplasm] (Caenorhabditis elegans)

Eip75B [nucleoplasm] (Drosophila melanogaster)

PPARA [nucleoplasm] (Bos taurus)

PPARA [nucleoplasm] (Canis familiaris)

PPARA [nucleoplasm] (Gallus gallus)

PPARA [nucleoplasm] (Sus scrofa)

pparab [nucleoplasm] (Danio rerio)

nhr-7 [nucleoplasm] (Caenorhabditis elegans)

nhr-85 [nucleoplasm] (Caenorhabditis elegans)

sex-1 [nucleoplasm] (Caenorhabditis elegans)

Ppara [nucleoplasm] (Mus musculus)

Ppara [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_005261712.1, XP_006724332.1, NP_005027.2, XP_011528542.1, XP_011528544.1, NP_001001928.1, XP_005261713.1, XP_006724333.1, XP_011528545.1, XP_011528543.1, XP_011528541.1

ZINC - World Drugs

PPARA_HUMAN

OpenTargets

ENSG00000186951

ZINC - FDA approved

PPARA_HUMAN

ZINC - Substances

PPARA_HUMAN

ZINC target

Q07869

ZINC - Biogenic

PPARA_HUMAN

PRO

Q07869

PDB

3ET1, 2NPA, 4BCR, 5HYK, 6KXY, 3G8I, 3KDU, 5AZT, 1I7G, 3SP6, 6KXX, 2ZNN, 3VI8, 3FEI, 1KKQ, 6L96, 4CI4, 2P54, 1K7L, 2REW, 3KDT

ZINC - Investigational

PPARA_HUMAN

ZINC - Metabolites

PPARA_HUMAN

HPA

ENSG00000186951-PPARA

GeneCards

Q07869

Ensembl

ENSG00000186951, ENST00000407236, ENSP00000262735, ENSP00000385523, ENST00000402126, ENSP00000385246, ENST00000262735

ZINC - Predictions - Purchasable

PPARA_HUMAN

Orphanet

25438

HMDB Protein

HMDBP02209

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.658	3
UniProt:Q9Y618 NCOR2	2	NCOR2 [nucleoplasm] (R-HSA-442469) SUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904)	0.646	3
UniProt:Q13133 NR1H3	1	NR1H3 [nucleoplasm] (R-HSA-8854957)	0.611	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.57	3
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [cytosol] (R-HSA-1181251)	0.556	3
UniProt:P22607 FGFR3	40	FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 795fs139 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419) p-6Y-FGFR3 S371C [plasma membrane] (R-HSA-2011886) p-6Y-FGFR3 G370C [plasma membrane] (R-HSA-2011883) p-6Y-FGFR3 Y373C [plasma membrane] (R-HSA-2011889) p-6Y-FGFR3 795fs139 [plasma membrane] (R-HSA-2038360) p-6Y-FGFR3 R248C [plasma membrane] (R-HSA-2011884) pY-FGFR3 [plasma membrane] (R-HSA-2038368) p-6Y-FGFR3 K650Q [plasma membrane] (R-HSA-2032962) p-6Y-FGFR3 K650N [plasma membrane] (R-HSA-2032961) p-6Y-FGFR3 K650E [plasma membrane] (R-HSA-2032952) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853147) p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853155) p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853145) p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853129) p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853151) p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853128) FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127)	0.556	3
UniProt:P06396 GSN	7	GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q14957 GRIN2C	3	p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:P45973 CBX5	2	SUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849) CBX5 [nucleoplasm] (R-HSA-994093)	0.556	3
UniProt:D3DTS7 D3DTS7			0.556	3
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.556	3
UniProt:P02768-3 ALB			0.556	3
UniProt:P55212 CASP6	5	CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:P13473-2 P134732			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128fs3 [cytosol] (R-HSA-3642173) TGFBR2 K128fs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:Q3L8U1-3 CHD9			0.524	2
UniProt:Q92569 PIK3R3	2	K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574) PIK3R3 [cytosol] (R-HSA-205223)	0.488	2

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