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PPARA [nucleoplasm]
Stable Identifier
R-HSA-400186
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Peroxisome proliferator-activated receptor alpha, PPAR-alpha
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9Y618%20NCOR2
Expand all
Circadian Clock (Homo sapiens)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (Homo sapiens)
Expression of PPARA (Homo sapiens)
PPARA [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of PPARA (Homo sapiens)
PPARA [nucleoplasm] (Homo sapiens)
PPARA binds RXRA (Homo sapiens)
PPARA [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS4 SUMOylates PPARA with SUMO1 (Homo sapiens)
PPARA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q07869 PPARA
Gene Names
PPARA, NR1C1, PPAR
Chain
chain:1-468
Reference Genes
BioGPS Gene:5465 PPARA
COSMIC (genes):PPARA PPARA
CTD Gene:5465 PPARA
dbSNP Gene:5465 PPARA
ENSEMBL:ENSG00000186951 PPARA
ENSEMBL_homo_sapiens_GENE:ENSG00000186951.17 PPARA
HGNC:9232 PPARA
KEGG Gene (Homo sapiens):5465 PPARA
Monarch:5465 PPARA
NCBI Gene:5465 PPARA
OMIM:170998 PPARA
UCSC:Q07869 PPARA
Reference Transcript
RefSeq:NM_005036.4 PPARA
RefSeq:XM_011530243.2 PPARA
RefSeq:XM_005261656.3 PPARA
RefSeq:XM_006724270.3 PPARA
RefSeq:NM_001001928.2 PPARA
RefSeq:XM_005261655.3 PPARA
RefSeq:XM_011530240.2 PPARA
RefSeq:XM_006724269.3 PPARA
RefSeq:XM_011530239.2 PPARA
RefSeq:XM_011530242.2 PPARA
RefSeq:XM_011530241.2 PPARA
Other Identifiers
11724411_a_at
11724412_a_at
11724413_s_at
11758903_at
11763524_a_at
1556064_PM_at
1556064_at
1558631_PM_at
1558631_at
16931339
16931358
206870_PM_at
206870_at
223437_PM_at
223437_at
223438_PM_s_at
223438_s_at
226978_PM_at
226978_at
244689_PM_at
244689_at
3948959
3948962
3948974
3948980
3948981
3948983
3948986
3948987
3948992
3948994
3948995
3948996
3948997
3948998
3948999
3949000
3949001
3949002
3949003
3949010
47512_at
5465
59974_r_at
8073826
86444_at
90256_at
929_at
A_14_P133767
A_23_P211643
A_24_P417036
A_24_P570049
A_32_P198371
GE62555
GE83467
GE87082
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001216
GO:0001223
GO:0001227
GO:0001228
GO:0001666
GO:0003012
GO:0003013
GO:0003677
GO:0003700
GO:0003707
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005975
GO:0006091
GO:0006094
GO:0006351
GO:0006355
GO:0006357
GO:0006629
GO:0006631
GO:0006954
GO:0007154
GO:0007155
GO:0007507
GO:0008270
GO:0008289
GO:0008544
GO:0009267
GO:0009755
GO:0010468
GO:0010565
GO:0010745
GO:0010883
GO:0010887
GO:0010891
GO:0012501
GO:0014070
GO:0019216
GO:0019217
GO:0019902
GO:0019904
GO:0023052
GO:0030154
GO:0030512
GO:0030522
GO:0031435
GO:0031624
GO:0032000
GO:0032091
GO:0032099
GO:0032868
GO:0032922
GO:0035095
GO:0038023
GO:0042060
GO:0042157
GO:0042752
GO:0043226
GO:0043401
GO:0043565
GO:0044877
GO:0045471
GO:0045722
GO:0045776
GO:0045820
GO:0045893
GO:0045944
GO:0046321
GO:0046872
GO:0046889
GO:0048511
GO:0048856
GO:0050728
GO:0051525
GO:0051716
GO:0051898
GO:0055086
GO:0060089
GO:0061052
GO:0061629
GO:0070166
GO:0097371
GO:0140110
GO:0140297
GO:1900016
GO:1901135
GO:1901215
GO:1902894
GO:1903038
GO:1903427
GO:1903944
GO:1904189
GO:2000191
GO:2000272
GO:2001171
HMNXSV003000005
HMNXSV003014939
Hs.272006.0.A1_3p_at
Hs.272006.0.A1_3p_x_at
Hs.275711.0.S2_3p_at
Hs.286014.0.S1_3p_at
Hs2.199700.1.A1_3p_at
Hs2.391179.1.A1_3p_at
ILMN_1659346
ILMN_1700488
ILMN_2362847
L02932_at
PH_hs_0023352
PH_hs_0026238
PH_hs_0034827
PH_hs_0035085
TC22000391.hg
TC22000392.hg
TC22001154.hg
TC22001155.hg
TC22001156.hg
g13278779_3p_a_at
g7549810_3p_at
p28699
p33879
Participates
as an input of
PIAS4 SUMOylates PPARA with SUMO1 (Homo sapiens)
PPARA binds RXRA (Homo sapiens)
as a member of
NR [nucleoplasm] (Homo sapiens)
as an output of
Expression of PPARA (Homo sapiens)
as a component of
PPARA:RXRA heterodimer [nucleoplasm] (Homo sapiens)
PPARA:fatty acid (Activated PPARA) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K185-PPARA [nucleoplasm]
Inferred To
nhr-2 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of PPARA [nucleoplasm]
(Caenorhabditis elegans)
Eip75B [nucleoplasm]
(Drosophila melanogaster)
PPARA [nucleoplasm]
(Bos taurus)
PPARA [nucleoplasm]
(Canis familiaris)
PPARA [nucleoplasm]
(Gallus gallus)
PPARA [nucleoplasm]
(Sus scrofa)
nhr-7 [nucleoplasm]
(Caenorhabditis elegans)
nhr-85 [nucleoplasm]
(Caenorhabditis elegans)
ppara [nucleoplasm]
(Danio rerio)
ppara [nucleoplasm]
(Xenopus tropicalis)
sex-1 [nucleoplasm]
(Caenorhabditis elegans)
Ppara [nucleoplasm]
(Mus musculus)
Ppara [nucleoplasm]
(Rattus norvegicus)
unc-55 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_011528542.1
,
XP_011528544.1
,
XP_006724333.1
,
XP_005261712.1
,
NP_001001928.1
,
XP_011528543.1
,
XP_011528541.1
,
XP_005261713.1
,
XP_011528545.1
,
NP_005027.2
,
XP_006724332.1
ZINC - World Drugs
PPARA_HUMAN
Guide to Pharmacology - Targets
593
OpenTargets
ENSG00000186951
ZINC - FDA approved
PPARA_HUMAN
ZINC - Substances
PPARA_HUMAN
ZINC - Biogenic
PPARA_HUMAN
ZINC target
Q07869
PRO
Q07869
PDB
6KAY
,
6LX6
,
1I7G
,
3ET1
,
6KB1
,
6LX7
,
3G8I
,
2NPA
,
5AZT
,
6KAZ
,
6KB0
,
3SP6
,
7BQ3
,
7BQ2
,
4CI4
,
6KAX
,
2P54
,
6KB4
,
6KB5
,
7C6Q
,
7BQ1
,
6L96
,
6LXA
,
4BCR
,
3KDT
,
6KB2
,
1KKQ
,
6KBA
,
2REW
,
6L36
,
6KB3
,
6L37
,
1K7L
,
6LX9
,
6KB8
,
7BQ4
,
6KB9
,
6KYP
,
6LX8
,
6KB6
,
5HYK
,
6KB7
,
6LX4
,
6LX5
,
7E5I
,
7BPZ
,
6LXC
,
2ZNN
,
6KXY
,
6L38
,
6KXX
,
7BQ0
,
7E5H
,
3VI8
,
3KDU
,
7E5G
,
7BPY
,
6LXB
,
7E5F
,
3FEI
ZINC - Investigational
PPARA_HUMAN
ZINC - Metabolites
PPARA_HUMAN
GeneCards
Q07869
HPA
ENSG00000186951-PPARA
Ensembl
ENSG00000186951
,
ENSP00000385523
,
ENST00000407236
,
ENST00000402126
,
ENSP00000385246
Pharos - Targets
Q07869
Orphanet
25438
ZINC - Predictions - Purchasable
PPARA_HUMAN
HMDB Protein
HMDBP02209
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75376 NCOR1
2
NCOR1 [cytosol]
(R-HSA-1253310)
NCOR1 [nucleoplasm]
(R-HSA-442501)
0.658
3
UniProt:Q9Y618 NCOR2
2
monoSUMO1-K672-NCOR2 [nucleoplasm]
(R-HSA-3927904)
NCOR2 [nucleoplasm]
(R-HSA-442469)
0.646
3
UniProt:Q13133 NR1H3
1
NR1H3 [nucleoplasm]
(R-HSA-8854957)
0.611
5
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.57
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:D3DTS7 D3DTS7
0.556
3
UniProt:P62826 RAN
2
RAN [nucleoplasm]
(R-HSA-165528)
RAN [cytosol]
(R-HSA-165540)
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
UniProt:P13473-2 P134732
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:P02768-3 ALB
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P06307 CCK
1
CCK [extracellular region]
(R-HSA-388539)
0.556
3
UniProt:P55212 CASP6
5
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
0.556
3
UniProt:Q14957 GRIN2C
3
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
GRIN2C [plasma membrane]
(R-HSA-419560)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
0.556
3
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.556
3
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [cytosol]
(R-HSA-1181251)
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:Q3L8U1-3 CHD9
0.524
2
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.488
2
UniProt:P0DTD1-PRO_0000449633 REP
0.488
2
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