Beta-TrCP1 binds phosphorylated PER proteins

Stable Identifier
R-HSA-400219
Type
Reaction
Species
Homo sapiens
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Summation

Beta-TrCP1 is an F-box type component of a particular SKP/CUL/F-Box (SCF) E3 ubiquitin ligase. Beta-TrCP1 interacts specifically with phosphorylated PER proteins and directs their polyubiquitination.

Literature References
PubMed ID Title Journal Year
15917222 SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein

Shirogane, T, Jin, J, Ang, XL, Harper, JW

J Biol Chem 2005
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