Reactome: A Curated Pathway Database

BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins

Stable Identifier
R-HSA-400267
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Polyubiquitination of PER proteins is directed by the Beta-TrCP1 component of SCF E3 ubiquitin ligase. The polyubiquitinated PER proteins are recognized and degraded by the 26S proteasome. Degradation of PER proteins occurs during the night and is necessary to allow new transcription of BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) targets in the morning during the circadian cycle.

Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
ubiquitin-protein transferase activity of BTRC:CUL1:SKP1 [cytosol] BTRC:CUL1:SKP1 [cytosol] ubiquitin-protein transferase activity (0004842)
Inferred From