Reactome: A Curated Pathway Database

CRY proteins are ubiquitinylated

Stable Identifier
R-HSA-400282
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Polyubiquitination of CRY proteins is directed by the FBXL3 component of SCF E3 ubiquitin ligase. The polyubiquitinated CRY proteins are recognized and degraded by the 26S proteasome. Degradation of CRY proteins occurs during the night and is necessary to allow new transcription of BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) targets in the morning during the circadian cycle.

Participants
Participant Of
hasEvent
Inferred From