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RORA [nucleoplasm]
Stable Identifier
R-HSA-400325
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear receptor ROR-alpha, RORA_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P51843 NR0B1
Expand all
Circadian clock (Homo sapiens)
Expression of BMAL (ARNTL), CLOCK, and NPAS2 (Homo sapiens)
RORA and EP300 bind NPAS2 gene (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes (Homo sapiens)
Phosphorylated BMAL1:CLOCK positively regulates expression of RORA (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression (Homo sapiens)
RORA and EP300 bind the Carnitine O-palmitoyltransferase 1 (CPT1A) gene (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA and EP300 bind the SREBF1 (SREBP1) gene (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS2,3,4 SUMOylate RORA with SUMO1 (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
PIAS2,3,4 SUMOylate RORA with SUMO2 (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35398 RORA
Gene Names
RORA, NR1F1, RZRA
Chain
chain:1-523
Reference Genes
BioGPS Gene:6095 RORA
COSMIC (genes):RORA RORA
CTD Gene:6095 RORA
dbSNP Gene:6095 RORA
ENSEMBL:ENSG00000069667 RORA
HGNC:10258 RORA
KEGG:hsa:6095 RORA
Monarch:6095 RORA
NCBI Gene:6095 RORA
OMIM:600825 RORA
UCSC:P35398 RORA
Reference Transcript
RefSeq:NM_134261.3 RORA
RefSeq:NM_134262.2 RORA
RefSeq:NM_002943.3 RORA
RefSeq:NM_134260.3 RORA
Participates
as an input of
PIAS2,3,4 SUMOylate RORA with SUMO2 (Homo sapiens)
PIAS2,3,4 SUMOylate RORA with SUMO1 (Homo sapiens)
RORA and EP300 bind the Carnitine O-palmitoyltransferase 1 (CPT1A) gene (Homo sapiens)
RORA and EP300 bind the SREBF1 (SREBP1) gene (Homo sapiens)
RORA and EP300 bind NPAS2 gene (Homo sapiens)
as a member of
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
RORA,RORC [nucleoplasm] (Homo sapiens)
RORA,B,C [nucleoplasm] (Homo sapiens)
as a component of
RORA:EP300:CPT1A gene [nucleoplasm] (Homo sapiens)
RORA:EP300:SREBF1 gene [nucleoplasm] (Homo sapiens)
RORA:EP300:NPAS2 gene [nucleoplasm] (Homo sapiens)
RORA:Coactivator [nucleoplasm] (Homo sapiens)
as an output of
Phosphorylated BMAL1:CLOCK positively regulates expression of RORA (Homo sapiens)
Other forms of this molecule
monoSUMO1-K240-RORA [nucleoplasm]
polySUMO2-K240-RORA [nucleoplasm]
Inferred To
Rora [nucleoplasm]
(Mus musculus)
Rora [nucleoplasm]
(Rattus norvegicus)
nhr-23 [nucleoplasm]
(Caenorhabditis elegans)
RORA [nucleoplasm]
(Bos taurus)
RORA [nucleoplasm]
(Canis familiaris)
RORA [nucleoplasm]
(Gallus gallus)
RORA [nucleoplasm]
(Sus scrofa)
Hr3 [nucleoplasm]
(Drosophila melanogaster)
roraa [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_599024.1
,
NP_599023.1
,
NP_002934.1
,
NP_599022.1
ZINC - World Drugs
RORA_HUMAN
Guide to Pharmacology - Targets
598
OpenTargets
ENSG00000069667
ENSEMBL
ENSP00000261523
,
ENSG00000069667
,
ENSP00000335087
,
ENST00000261523
,
ENST00000335670
ZINC - Substances
RORA_HUMAN
ZINC - Biogenic
RORA_HUMAN
ZINC target
P35398
PRO
P35398
GlyGen
P35398
PDB
4S15
,
1N83
,
1S0X
ZINC - Metabolites
RORA_HUMAN
HPA
ENSG00000069667-RORA
GeneCards
RORA
Pharos - Targets
P35398
ZINC - Predictions - Purchasable
RORA_HUMAN
Orphanet
RORA
HMDB Protein
HMDBP02591
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P62195 PSMC5
2
PSMC5 [cytosol]
(R-HSA-68780)
PSMC5 [nucleoplasm]
(R-HSA-174312)
0.553
2
UniProt:P51843 NR0B1
0.508
2
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