Free fatty acids regulate insulin secretion

Stable Identifier
R-HSA-400451
Type
Pathway
Species
Homo sapiens
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Free fatty acids augment the glucose-triggered secretion of insulin. The augmentation is believed to be due to the additive effects of the activation of the free fatty acid receptor 1 (FFAR1 or GPR40) and the metabolism of free fatty acids within the pancreatic beta cell. This module describes each pathway.

Literature References
PubMed ID Title Journal Year
17130640 Fatty acid signaling in the beta-cell and insulin secretion

Nolan, CJ, Madiraju, MS, Delghingaro-Augusto, V, Peyot, ML, Prentki, M

Diabetes 2006
17395749 GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo

Latour, MG, Alquier, T, Oseid, E, Tremblay, C, Jetton, TL, Luo, J, Lin, DC, Poitout, V

Diabetes 2007
18827341 Free fatty acid receptors and drug discovery

Hirasawa, A, Hara, T, Katsuma, S, Adachi, T, Tsujimoto, G

Biol Pharm Bull 2008
15047616 A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli

Roduit, R, Nolan, C, Alarcon, C, Moore, P, Barbeau, A, Delghingaro-Augusto, V, Przybykowski, E, Morin, J, Massé, F, Massie, B, Ruderman, N, Rhodes, C, Poitout, V, Prentki, M

Diabetes 2004
18606873 Glycerolipid metabolism and signaling in health and disease

Prentki, M, Madiraju, SR

Endocr Rev 2008
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