Free fatty acids regulate insulin secretion

Stable Identifier
R-HSA-400451
Type
Pathway
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Free fatty acids regulate insulin secretion
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Free fatty acids augment the glucose-triggered secretion of insulin. The augmentation is believed to be due to the additive effects of the activation of the free fatty acid receptor 1 (FFAR1 or GPR40) and the metabolism of free fatty acids within the pancreatic beta cell. This module describes each pathway.
Literature References
PubMed ID Title Journal Year
17395749 GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo

Latour, MG, Alquier, T, Oseid, E, Tremblay, C, Jetton, TL, Luo, J, Lin, DC, Poitout, V

Diabetes 2007
17130640 Fatty acid signaling in the beta-cell and insulin secretion

Nolan, CJ, Madiraju, MS, Delghingaro-Augusto, V, Peyot, ML, Prentki, M

Diabetes 2006
18827341 Free fatty acid receptors and drug discovery

Hirasawa, A, Hara, T, Katsuma, S, Adachi, T, Tsujimoto, G

Biol Pharm Bull 2008
15047616 A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli

Roduit, R, Nolan, C, Alarcon, C, Moore, P, Barbeau, A, Delghingaro-Augusto, V, Przybykowski, E, Morin, J, Massé, F, Massie, B, Ruderman, N, Rhodes, C, Poitout, V, Prentki, M

Diabetes 2004
18606873 Glycerolipid metabolism and signaling in health and disease

Prentki, M, Madiraju, SR

Endocr Rev 2008
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Event Information
Go Biological Process
positive regulation of insulin secretion (0032024)
Orthologous Events
Free fatty acids regulate insulin secretion (Bos taurus)
Free fatty acids regulate insulin secretion (Caenorhabditis elegans)
Free fatty acids regulate insulin secretion (Canis familiaris)
Free fatty acids regulate insulin secretion (Danio rerio)
Free fatty acids regulate insulin secretion (Dictyostelium discoideum)
Free fatty acids regulate insulin secretion (Drosophila melanogaster)
Free fatty acids regulate insulin secretion (Gallus gallus)
Free fatty acids regulate insulin secretion (Mus musculus)
Free fatty acids regulate insulin secretion (Rattus norvegicus)
Free fatty acids regulate insulin secretion (Saccharomyces cerevisiae)
Free fatty acids regulate insulin secretion (Schizosaccharomyces pombe)
Free fatty acids regulate insulin secretion (Sus scrofa)
Free fatty acids regulate insulin secretion (Xenopus tropicalis)
Authored
May, B  (2009-06-08)
Reviewed
Poitout, V  (2009-09-09)
Kebede, M  (2009-09-09)
Madiraju, MS  (2009-10-02)
Created
May, B  (2009-03-24)
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