Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
GIP(52-93) [secretory granule lumen]
Stable Identifier
R-HSA-400483
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
Glucose-dependent Insulinotropic Polypeptide, Gastric Inhibitory Peptide, GIP
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Homo sapiens)
GIP(52-93) [secretory granule lumen] (Homo sapiens)
PCSK1 hydrolyzes proGIP to GIP (Homo sapiens)
GIP(52-93) [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09681 GIP
Gene Names
GIP
Chain
signal peptide:1-21, propeptide:22-50, peptide:52-93, propeptide:95-153
Reference Genes
BioGPS Gene:2695 GIP
COSMIC (genes):GIP GIP
CTD Gene:2695 GIP
dbSNP Gene:2695 GIP
ENSEMBL:ENSG00000159224 GIP
HGNC:4270 GIP
KEGG Gene (Homo sapiens):2695 GIP
Monarch:2695 GIP
NCBI Gene:2695 GIP
OMIM:137240 GIP
UCSC:P09681 GIP
Reference Transcript
RefSeq:NM_004123.2 GIP
Other Identifiers
0000460204
11734238_at
16846363
207899_at
2695
3761662
3761663
3761665
3761666
3761667
3761669
3761670
611_at
8016523
A_23_P141459
GE57854
GO:0000003
GO:0003674
GO:0005102
GO:0005179
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0006629
GO:0006810
GO:0006950
GO:0007165
GO:0007186
GO:0007267
GO:0007565
GO:0007613
GO:0008150
GO:0008344
GO:0009058
GO:0009743
GO:0009749
GO:0010269
GO:0010447
GO:0010828
GO:0014070
GO:0015031
GO:0019233
GO:0031018
GO:0031410
GO:0031667
GO:0031769
GO:0032024
GO:0033993
GO:0034774
GO:0035640
GO:0042304
GO:0042493
GO:0042592
GO:0042594
GO:0043025
GO:0043200
GO:0043226
GO:0043434
GO:0043950
GO:0044281
GO:0048678
GO:0048856
GO:0050796
GO:0050806
GO:0050877
GO:0055085
GO:0055123
GO:0060291
GO:0070094
GO:0070328
ILMN_1673805
M18185_at
PH_hs_0000196
TC17001657.hg
g4758435_3p_at
Participant Of
output
PCSK1 hydrolyzes proGIP to GIP
input
Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells
Other forms of this molecule
GIP(22-153) [endoplasmic reticulum lumen]
GIP(22-153) [secretory granule lumen]
GIP(54-93) [extracellular region]
GIP(1-153) [endoplasmic reticulum lumen]
GIP(52-93) [extracellular region]
Inferred To
GIP(52-93) [secretory granule lumen] (Gallus gallus)
GIP(52-93) [secretory granule lumen] (Xenopus tropicalis)
GIP [secretory granule lumen] (Canis familiaris)
gip [secretory granule lumen] (Danio rerio)
Gip [secretory granule lumen] (Mus musculus)
Gip [secretory granule lumen] (Rattus norvegicus)
Cross References
RefSeq
NP_004114.1
OpenTargets
ENSG00000159224
ZINC - Substances
GIP_HUMAN
HPA
ENSG00000159224-GIP
GeneCards
P09681
ZINC target
P09681
Ensembl
ENSP00000350005
,
ENSG00000159224
,
ENST00000357424
PRO
P09681
ZINC - Predictions - Purchasable
GIP_HUMAN
PDB
2QKH
,
2L71
,
2B4N
,
1T5Q
,
2OBU
,
2L70
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.718
6
UniProt:P48546 GIPR
1
GIPR [plasma membrane]
(R-HSA-420132)
0.618
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:Q96EQ0 SGTB
0.556
3
UniProt:Q7Z3S9 NT2NA
0.556
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text