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PCSK1 hydrolyzes proGIP to GIP
Stable Identifier
R-HSA-400492
Type
Reaction [transition]
Species
Homo sapiens
Compartment
secretory granule lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
PCSK1 hydrolyzes proGIP to GIP (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Prohormone Convertase 1/3 in secretory granules cleaves Glucose Insulinotropic Polypeptide at Arg51 and Arg93, liberating the mature 42 amino acid GIP molecule.
Participants
Input
GIP(22-153) [secretory granule lumen]
(Homo sapiens)
Output
GIP(52-93) [secretory granule lumen]
(Homo sapiens)
Participates
as an event of
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
Catalyst Activity
serine-type endopeptidase activity of PC1:calcium cofactor [secretory granule lumen]
Physical Entity
PC1:calcium cofactor [secretory granule lumen]
(Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Pcsk1 hydrolyzes ProGip to Gip (Mus musculus)
Authored
May, B (2009-05-19)
Reviewed
Bloom, SR (2010-06-25)
Created
May, B (2009-03-24)
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