PCSK1 hydrolyzes proGIP to GIP

Stable Identifier
R-HSA-400492
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Prohormone Convertase 1/3 in secretory granules cleaves Glucose Insulinotropic Polypeptide at Arg51 and Arg93, liberating the mature 42 amino acid GIP molecule.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of PC1:calcium cofactor [secretory granule lumen]
Physical Entity
Activity
Inferred From