PCSK1 hydrolyzes proGIP to GIP

Stable Identifier
R-HSA-400492
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Prohormone Convertase 1/3 in secretory granules cleaves Glucose Insulinotropic Polypeptide at Arg51 and Arg93, liberating the mature 42 amino acid GIP molecule.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of PC1:calcium cofactor [secretory granule lumen]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
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