Signal peptidase hydrolyzes preproGIP to proGIP

Stable Identifier
R-HSA-400496
Type
Reaction
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
Locations in the PathwayBrowser
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Summation

The GIP mRNA is translated by ribosomes at the outer surface of the rough endoplasmic reticulum. The nascent peptide enters the endoplasmic reticulum through the translocon complex and the signal peptide is cleaved by the signal peptidase.

Literature References
PubMed ID Title Journal Year
2890159 Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor

Takeda, J, Seino, Y, Tanaka, K, Fukumoto, H, Kayano, T, Takahashi, H, Mitani, T, Kurono, M, Suzuki, T, Tobe, T

Proc Natl Acad Sci U S A 1987
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]
Physical Entity
Signal Peptidase [endoplasmic reticulum membrane]
Activity
serine-type endopeptidase activity (0004252)
Inferred From
Signal Peptidase (Canis) hydrolyzes the signal peptide of Preprolactin (Bos taurus)
Authored
May, B  (2009-05-19)
Reviewed
Bloom, SR  (2010-06-25)