Signal peptidase hydrolyzes preproGIP to proGIP

Stable Identifier
R-HSA-400496
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The GIP mRNA is translated by ribosomes at the outer surface of the rough endoplasmic reticulum. The nascent peptide enters the endoplasmic reticulum through the translocon complex and the signal peptide is cleaved by the signal peptidase.

Literature References
PubMed ID Title Journal Year
2890159 Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor Proc Natl Acad Sci U S A 1987
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]
Physical Entity
Activity
Inferred From