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Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells

Stable Identifier
R-HSA-400500
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The transcription factors PDX-1 and PAX6 binds the promoter of the human GIP gene between 145 and 184 nucleotides upstream of the start of transcription and enhance transcription of GIP. In mouse Pdx-1 also increases the number of GIP-producing K cells. Consensus binding sites for other transcription factors such as AP-1, AP-2, and Sp1 have been identified in the promoter of the GIP gene but their role is unknown. The human GIP promoter is responsive to cAMP by an unknown mechanism.

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