Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells

Stable Identifier
R-HSA-400509
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
secretory granule lumen, extracellular region
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Summation

GIP is secreted by intestinal K-cells in response to glucose, amino acids, and fats. In mice fatty acids act to increase GIP secretion by binding the G-protein coupled receptors GPR40 and GPR119 present on intestinal K-cells. The stimulation is dependent on adenyl cyclase and intracellular calcium but the exact mechanism is unknown.

Literature References
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Participant Of
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This entity is regulated by
Positive Regulation
Orthologous Events
Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Bos taurus)
Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Canis familiaris)
Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Mus musculus)
Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Rattus norvegicus)
Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Sus scrofa)