Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells

Stable Identifier
R-HSA-400509
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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Summation

GIP is secreted by intestinal K-cells in response to glucose, amino acids, and fats. In mice fatty acids act to increase GIP secretion by binding the G-protein coupled receptors GPR40 and GPR119 present on intestinal K-cells. The stimulation is dependent on adenyl cyclase and intracellular calcium but the exact mechanism is unknown.

Literature References
PubMed ID Title Journal Year
18519800 Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion

Edfalk, S, Steneberg, P, Edlund, H

Diabetes 2008
18202141 A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release

Chu, ZL, Carroll, C, Alfonso, J, Gutierrez, V, He, H, Lucman, A, Pedraza, M, Mondala, H, Gao, H, Bagnol, D, Chen, R, Jones, RM, Behan, DP, Leonard, J

Endocrinology 2008
16219666 Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP

Theodorakis, MJ, Carlson, O, Michopoulos, S, Doyle, ME, Juhaszova, M, Petraki, K, Egan, JM

Am J Physiol Endocrinol Metab 2006
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