GIP is secreted by intestinal K-cells in response to glucose, amino acids, and fats. In mice fatty acids act to increase GIP secretion by binding the G-protein coupled receptors GPR40 and GPR119 present on intestinal K-cells. The stimulation is dependent on adenyl cyclase and intracellular calcium but the exact mechanism is unknown.
Edfalk, S, Steneberg, P, Edlund, H
Chu, ZL, Carroll, C, Alfonso, J, Gutierrez, V, He, H, Lucman, A, Pedraza, M, Mondala, H, Gao, H, Bagnol, D, Chen, R, Jones, RM, Behan, DP, Leonard, J
Theodorakis, MJ, Carlson, O, Michopoulos, S, Doyle, ME, Juhaszova, M, Petraki, K, Egan, JM
© 2020 Reactome
