Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)

Stable Identifier
Homo sapiens
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In K cells of the intestine the transcription factors PAX6 and PDX-1 activate transcription of the gene encoding Glucose-dependent Insulinotropic Polypeptide (GIP, first called Gastric Inhibitory Peptide). ProGIP is cleaved in secretory granules by Prohormone Convertase 1 (PC1) at 2 sites to yield mature GIP. In response to fat the GIP is secreted into the bloodstream. The half-life of GIP in the bloodstream is determined by Dipeptidyl Peptidase IV, which cleaves 2 amino acids at the amino terminus of GIP, rendering it biologically inactive.

Literature References
PubMed ID Title Journal Year
17263764 Incretins and other peptides in the treatment of diabetes Diabet Med 2007
19074620 The role of incretins in glucose homeostasis and diabetes treatment Pharmacol Rev 2008
17498508 Biology of incretins: GLP-1 and GIP Gastroenterology 2007
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