Reactome: A Curated Pathway Database

DPP4 hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)

Stable Identifier
R-HSA-400513
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Dipeptidyl Peptidase IV (DPP4) cleaves 2 amino acids from the N-terminus of GIP, inactivating it. DPP4 determines the half life of GIP in the bloodstream. It is unknown if the soluble form of DPP4, the membrane-bound form, or both catalyze the cleavage of GIP.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
serine-type endopeptidase activity of DPP4(39-766) [extracellular region] DPP4(39-766) [extracellular region] serine-type endopeptidase activity (0004252)
serine-type endopeptidase activity of DPP4(1-766) [plasma membrane] DPP4(1-766) [plasma membrane] serine-type endopeptidase activity (0004252)
Orthologous Events