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NKX2-5 [nucleoplasm]
Stable Identifier
R-HSA-4005994
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Homeobox protein Nkx-2.5, NKX25_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q8WUP2 FBLIM1
Expand all
Developmental Biology (Homo sapiens)
Cardiogenesis (Homo sapiens)
Expression of NKX2-5 in cardiogenesis (Homo sapiens)
NKX2-5 [nucleoplasm] (Homo sapiens)
FOXO4, MEF2C, and NKX2-5 bind the MYOCD gene (Homo sapiens)
NKX2-5 [nucleoplasm] (Homo sapiens)
GATA4 and NKX2-5 bind the HAND1 gene (Homo sapiens)
NKX2-5 [nucleoplasm] (Homo sapiens)
GATA4, ISL1:LDB1, TBX20, and NKX2-5 bind the MEF2C gene (Homo sapiens)
NKX2-5 [nucleoplasm] (Homo sapiens)
GATA4, SMAD1:SMAD4, MEF2C, TBX20, and NKX2-5 bind the NKX2-5 gene (Homo sapiens)
NKX2-5 [nucleoplasm] (Homo sapiens)
NKX2-5 binds the GATA4 gene (Homo sapiens)
NKX2-5 [nucleoplasm] (Homo sapiens)
NKX2-5 binds the GATA6 gene (Homo sapiens)
NKX2-5 [nucleoplasm] (Homo sapiens)
NKX2-5 binds the TBX5 gene (Homo sapiens)
NKX2-5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52952 NKX2-5
Gene Names
NKX2-5, CSX, NKX2.5, NKX2E
Chain
chain:1-324
Reference Genes
BioGPS Gene:1482 NKX2-5
COSMIC (genes):NKX2-5 NKX2-5
CTD Gene:1482 NKX2-5
dbSNP Gene:1482 NKX2-5
ENSEMBL:ENSG00000183072 NKX2-5
HGNC:2488 NKX2-5
KEGG:hsa:1482 NKX2-5
Monarch:1482 NKX2-5
NCBI Gene:1482 NKX2-5
OMIM:600584 NKX2-5
UCSC:P52952 NKX2-5
Reference Transcript
RefSeq:NM_001166176.1 NKX2-5
RefSeq:NM_001166175.1 NKX2-5
RefSeq:NM_004387.3 NKX2-5
Other Identifiers
11728859_at
11761300_a_at
1482
17002879
206578_PM_at
206578_at
2887462
2887463
2887464
2887465
2887466
2887467
2887468
2887469
2887470
2887471
33570_at
8115840
A_23_P396135
A_33_P3299599
GE59102
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001216
GO:0001228
GO:0001570
GO:0001947
GO:0003007
GO:0003012
GO:0003013
GO:0003148
GO:0003151
GO:0003161
GO:0003162
GO:0003166
GO:0003168
GO:0003180
GO:0003208
GO:0003211
GO:0003221
GO:0003222
GO:0003228
GO:0003278
GO:0003285
GO:0003342
GO:0003350
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006915
GO:0007010
GO:0007507
GO:0007512
GO:0008283
GO:0008284
GO:0010628
GO:0010667
GO:0010765
GO:0010832
GO:0012501
GO:0030097
GO:0030154
GO:0030855
GO:0030878
GO:0032991
GO:0032993
GO:0035050
GO:0042803
GO:0043066
GO:0043226
GO:0043565
GO:0045666
GO:0045823
GO:0045892
GO:0045893
GO:0045944
GO:0048536
GO:0048738
GO:0048856
GO:0050673
GO:0050679
GO:0051891
GO:0055005
GO:0055007
GO:0055008
GO:0055013
GO:0055014
GO:0055015
GO:0055117
GO:0060037
GO:0060038
GO:0060043
GO:0060047
GO:0060048
GO:0060261
GO:0060347
GO:0060411
GO:0060412
GO:0060413
GO:0060928
GO:0060929
GO:0060971
GO:0061629
GO:0090090
GO:0090575
GO:0140110
GO:1903779
GO:1904019
GO:1904036
GO:1990664
GO:1990837
HMNXSV003012923
HMNXSV003048815
ILMN_1800058
PH_hs_0031239
TC05002071.hg
U34962_at
g4758089_3p_at
Participates
as an input of
NKX2-5 binds the GATA4 gene (Homo sapiens)
GATA4 and NKX2-5 bind the HAND1 gene (Homo sapiens)
NKX2-5 binds the GATA6 gene (Homo sapiens)
GATA4, ISL1:LDB1, TBX20, and NKX2-5 bind the MEF2C gene (Homo sapiens)
FOXO4, MEF2C, and NKX2-5 bind the MYOCD gene (Homo sapiens)
NKX2-5 binds the TBX5 gene (Homo sapiens)
GATA4, SMAD1:SMAD4, MEF2C, TBX20, and NKX2-5 bind the NKX2-5 gene (Homo sapiens)
as a component of
GATA4:NKX2-5:HAND1 gene [nucleoplasm] (Homo sapiens)
NKX2-5:GATA6 gene [nucleoplasm] (Homo sapiens)
GATA4:ISL1:LDB1:NKX2-5:TBX20:MEF2C gene [nucleoplasm] (Homo sapiens)
FOXO4:MEF2C:NKX2-5:MYOCD gene [nucleoplasm] (Homo sapiens)
NKX2-5:TBX5 gene [nucleoplasm] (Homo sapiens)
NKX2-5:GATA4 gene [nucleoplasm] (Homo sapiens)
GATA4:SMAD1:SMAD4:MEF2C:NKX2-5:TBX20:NKX2-5 gene [nucleoplasm] (Homo sapiens)
NKX2-5:GATA4:HIPK1,2 [nucleoplasm] (Homo sapiens)
as an output of
Expression of NKX2-5 in cardiogenesis (Homo sapiens)
Cross References
ENSEMBL
ENST00000424406
,
ENSP00000427906
,
ENST00000329198
,
ENST00000521848
,
ENSP00000327758
,
ENSP00000395378
OpenTargets
ENSG00000183072
HPA
ENSG00000183072-NKX2-5
PRO
P52952
Pharos - Targets
P52952
Orphanet
NKX2-5
PDB
6WC2
,
4S0H
,
3RKQ
,
6WC5
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99593-1 TBX5
0.639
6
UniProt:O15266-2 SHOX
0.556
3
UniProt:Q8IUC2 KRTAP8-1
1
KRTAP8-1 [cytosol]
(R-HSA-6810288)
0.556
3
UniProt:Q15642-2 TRIP10
0.556
3
UniProt:Q93062-3 RBPMS
0.556
3
UniProt:Q8WUP2 FBLIM1
1
FBLIM1 [cytosol]
(R-HSA-430301)
0.547
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:P43694 GATA4
1
GATA4 [nucleoplasm]
(R-HSA-400553)
0.524
2
UniProt:Q71FD7
1
Fblim1 [cytosol]
(R-MMU-430301)
0.524
4
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