Sema4D in semaphorin signaling

Stable Identifier
R-HSA-400685
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser
Semaphorin 4D (Sema 4D/CD100) is an axon guidance molecule with two disulfide-linked 150-kDa subunits. SEMA4D is structurally defined by a conserved 500-amino acid extracellular domain with 16 cysteines (sema domain) and also an Ig-like domain C-terminal to the sema domain. Sema4D is expressed on the cell surface as a homodimer; cysteine 679 within the sema domain is required for this dimerization.
The main receptors for Sema4D are plexin-B1 and CD72. The activation of plexins by semaphorins initiates a variety of signaling processes that involve several small GTPases of the Ras and Rho families. Sema4D-Plexin-B1 interaction appears to mediate different and sometimes opposite effects depending on the cellular context. Plexin-B1 activation inhibits integrin-mediated cell attachment and cell migration through the activation of the R-RasGAP activity inherent to plexin-B1 or through the inhibition of RhoA. However, activation of plexin-B1 by Sema4D stimulates the migration of endothelial cells by mediating the activation of RhoA.
Literature References
PubMed ID Title Journal Year
14770294 Biological functions and signaling of a transmembrane semaphorin, CD100/Sema4D

Kumanogoh, A, Kikutani, H

Cell Mol Life Sci 2004
15818466 Plexins: axon guidance and signal transduction

Katoh, H, Oinuma, I, Negishi, M

Cell Mol Life Sci 2005
16314868 Semaphorins command cells to move

Guan, KL, Aurandt, J, Kruger, RP

Nat Rev Mol Cell Biol 2005
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!