NEU3 hydrolyzes Neu5Ac from glycoconjugates

Stable Identifier
Reaction [transition]
Homo sapiens
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Sialidases 1-4 (NEU1-4, neuraminidases, receptor-destroying enzymes, RDEs) hydrolyze sialic acids (N-acetylneuraminic acid, Neu5Ac) to produce asialo compounds, a step in the degradation process of glycoproteins and gangliosides and are expressed in a variety of cellular locations. NEU3 localizes to the plasma membrane and hydrolyses Neu5Ac especially from gangliosides with alpha2,3- or alpha2,8-linkages present in the lipid bilayer (Wada et al. 1999, Monti et al. 2000). By regulating the composition of the lipid bilayer, NEU3 has been identified as an important regulator of trans-membrane signaling (Miyagi et al. 2008).
Literature References
PubMed ID Title Journal Year
10861246 Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane

Borsani, G, Preti, A, Manzoni, M, Papini, N, Venerando, B, Tettamanti, G, Bassi, MT, Ballabio, A, Croci, G, Riboni, M, Monti, E

Biochem J 2000
18632803 Plasma membrane-associated sialidase as a crucial regulator of transmembrane signalling

Hata, K, Wada, T, Miyagi, T, Shiozaki, K, Yamaguchi, K

J. Biochem. 2008
10405317 Cloning, expression, and chromosomal mapping of a human ganglioside sialidase

Miyagi, T, Wada, T, Tokuyama, S, Akita, H, Yoshikawa, Y, Kuwabara, M

Biochem. Biophys. Res. Commun. 1999
Catalyst Activity

exo-alpha-sialidase activity of NEU3 [plasma membrane]

Orthologous Events
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