LUM (lumican) binds integrin alpha2beta1

Stable Identifier
R-HSA-4085133
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Lumican (LUM) is the major leucine-rich keratan sulfate proteoglycan of the corneal stroma, also found in the extracellular matrices of skin, muscle and cartilage. Lum null mice have corneal opacity as well as skin and tendon fragility associated with disorganized and loosely packed collagen fibers (Jepsen et al. 2002, Chakravarti et al. 2003). LUM binds integrin alpha2beta1 (Zeltz et al. 2010), downregulating MMP-14 expression (Niewiarowska et al. 2011).

Literature References
PubMed ID Title Journal Year
20705068 Lumican inhibits cell migration through ?2?1 integrin

Zeltz, C, Brezillon, S, Käpylä, J, Eble, JA, Bobichon, H, Terryn, C, Perreau, C, Franz, CM, Heino, J, Maquart, FX, Wegrowski, Y

Exp. Cell Res. 2010
Participants
Participant Of
Orthologous Events
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