SUMO2,3-K263-NPM1 [nucleoplasm]

Stable Identifier
R-HSA-4086056
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Nucleophosmin, NPM_HUMAN
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
17535915 Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival

Liu, X, Liu, Z, Jang, SW, Ma, Z, Shinmura, K, Kang, S, Dong, S, Chen, J, Fukasawa, K, Ye, K

Proc. Natl. Acad. Sci. U.S.A. 2007
19240082 Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites

Blomster, HA, Hietakangas, V, Wu, J, Kouvonen, P, Hautaniemi, S, Sistonen, L

Mol. Cell Proteomics 2009
External Reference Information
External Reference
Gene Names
NPM1, NPM
Chain
chain:1-294
Other Identifiers
0000870408
11730790_x_at
11730912_at
11754066_x_at
11757362_x_at
11757386_x_at
18670158
18670159
18670165
18670166
18670167
200063_PM_s_at
200063_s_at
221691_3p_x_at
221691_x_at
221923_s_at
2326906
2666248
2840617
2840618
2840619
2840620
2840621
2840623
2840626
2840627
2840628
2840629
2840631
2840633
2840638
2840640
2840641
2840642
2840643
2840646
2840647
2840648
2867271
2867272
2867273
2867274
2867275
2867281
2867283
2960052
2960054
3100478
3100479
3136166
3404467
3404471
38542_at
4869
78344_at
7892530
7892853
7893382
7893420
7893571
7893657
7894485
7894919
7895119
7895225
7895472
7895509
7896054
8109975
8180407
8180408
8180409
88066_s_at
A_14_P116462
A_14_P127485
A_23_P214037
A_24_P188941
GE79895
GO:0000055
GO:0000056
GO:0001046
GO:0003674
GO:0003676
GO:0003677
GO:0003682
GO:0003713
GO:0003723
GO:0004860
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005925
GO:0006259
GO:0006281
GO:0006334
GO:0006338
GO:0006357
GO:0006407
GO:0006412
GO:0006464
GO:0006810
GO:0006886
GO:0006913
GO:0006950
GO:0007010
GO:0007049
GO:0007098
GO:0007165
GO:0007568
GO:0007569
GO:0008104
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008285
GO:0009056
GO:0009058
GO:0010824
GO:0010826
GO:0015031
GO:0016020
GO:0016032
GO:0019899
GO:0019901
GO:0022607
GO:0030234
GO:0030957
GO:0031616
GO:0032071
GO:0032991
GO:0032993
GO:0033613
GO:0034080
GO:0034641
GO:0034644
GO:0034655
GO:0042254
GO:0042255
GO:0042273
GO:0042274
GO:0042393
GO:0042803
GO:0043023
GO:0043024
GO:0043066
GO:0043226
GO:0044387
GO:0044403
GO:0045727
GO:0045893
GO:0045944
GO:0046599
GO:0051059
GO:0051082
GO:0051092
GO:0051276
GO:0060699
GO:0060735
GO:0065003
GO:1902629
GO:1902751
GO:1990904
Hs.9614.1.A1_3p_a_at
ILMN_1678775
ILMN_2379762
M23613_at
PH_hs_0030093
TC01000357.hg
TC05000942.hg
g12803184_3p_a_at
g13536990_3p_s_at
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 263
Coordinate
263
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Interactors (36)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q96BK5 PINX1      0.757 12
 UniProt:Q9H4L4 SENP3  1 0.718 6
 UniProt:Q00987 MDM2  11 0.697 5
 UniProt:P04637 TP53  27 0.676 6
 UniProt:P62753 RPS6  3 0.669 3
 UniProt:Q86SE8 NPM2      0.666 6
 UniProt:B1Q2W9 B1Q2W9      0.639 8
 UniProt:Q96GD4 AURKB  3 0.626 5
 UniProt:P24938 CORE5      0.623 4
 UniProt:Q6UPD4 Q6UPD4      0.619 4
 UniProt:Q9BZQ8 NIBA1      0.602 7
 UniProt:Q9BXL5 HEMGN      0.599 7
 UniProt:P49450 CENPA  2 0.597 4
 UniProt:P05549 TFAP2A  1 0.591 6
 UniProt:P68951 NP      0.591 5
 UniProt:P0DOE7 MATRX      0.576 3
 UniProt:O14746 TERT  1 0.576 5
 UniProt:P63104 YWHAZ  2 0.564 2
 UniProt:Q71RC2 LARP4      0.564 2
 UniProt:Q8N726 CDKN2A  12 0.564 2
 UniProt:P10176 COX8A  1 0.556 3
 UniProt:Q8IZL8 PELP1  1 0.556 3
 UniProt:Q86SE8-2 NPM2      0.556 5
 UniProt:P60228 EIF3E  1 0.547 2
 UniProt:P03372 ESR1  8 0.532 3
 UniProt:P19320 VCAM1  1 0.527 4
 UniProt:Q14684 RRP1B      0.527 3
 UniProt:Q98147 Q98147      0.524 2
 UniProt:Q13547 HDAC1  2 0.524 2
 UniProt:Q14684-1 RRP1B      0.512 4
 UniProt:Q10570 CPSF1  1 0.499 2
 UniProt:Q9UQ80 PA2G4  2 0.491 3
 UniProt:Q9BQG0 MYBBP1A  1 0.491 2
 UniProt:O14965 AURKA  6 0.489 3
 UniProt:P19525 EIF2AK2  1 0.463 3
 UniProt:P11387 TOP1  2 0.462 3
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