polySUMO2,3-K263-NPM1 [nucleoplasm]

Stable Identifier
R-HSA-4086056
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Nucleophosmin, NPM_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O14746 TERT
Literature References
PubMed ID Title Journal Year
17535915 Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival

Liu, X, Shinmura, K, Kang, S, Ma, Z, Jang, SW, Ye, K, Liu, Z, Fukasawa, K, Chen, J, Dong, S

Proc. Natl. Acad. Sci. U.S.A. 2007
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M

Nat. Struct. Mol. Biol. 2014
19240082 Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites

Sistonen, L, Wu, J, Blomster, HA, Hautaniemi, S, Kouvonen, P, Hietakangas, V

Mol. Cell Proteomics 2009
External Reference Information
External Reference
Gene Names
NPM1, NPM
Chain
chain:1-294
Other Identifiers
11730790_x_at
11730912_at
11754066_x_at
11757362_x_at
11757386_x_at
16656591
16656593
16656595
18670158
18670159
18670165
18670166
18670167
200063_PM_s_at
200063_s_at
221691_3p_x_at
221691_PM_x_at
221691_x_at
221923_PM_s_at
221923_s_at
2326906
2666248
2840617
2840618
2840620
2840621
2840623
2840626
2840627
2840628
2840629
2840631
2840633
2840638
2840640
2840641
2840642
2840643
2840646
2840647
2840648
2867271
2867272
2867273
2867274
2867275
2867281
2867283
2960052
2960054
3100478
3100479
3136166
3404467
3404471
38542_at
4869
78344_at
7892530
7892853
7893382
7893420
7893571
7893657
7894485
7894919
7895119
7895225
7895472
7895509
7896054
8109975
8180407
8180408
8180409
88066_s_at
A_14_P116462
A_14_P127485
A_23_P214037
A_24_P188941
GE79895
GO:0000055
GO:0000056
GO:0001046
GO:0001558
GO:0001652
GO:0003676
GO:0003677
GO:0003682
GO:0003713
GO:0003723
GO:0004860
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005840
GO:0005856
GO:0005925
GO:0006281
GO:0006325
GO:0006334
GO:0006338
GO:0006351
GO:0006355
GO:0006407
GO:0006884
GO:0006886
GO:0006913
GO:0007010
GO:0007098
GO:0007165
GO:0008104
GO:0008284
GO:0008285
GO:0010608
GO:0010629
GO:0010824
GO:0010825
GO:0010826
GO:0012501
GO:0015934
GO:0015935
GO:0016020
GO:0016071
GO:0016607
GO:0019843
GO:0019901
GO:0023052
GO:0030957
GO:0031328
GO:0031398
GO:0031616
GO:0031647
GO:0032071
GO:0032991
GO:0032993
GO:0034644
GO:0036211
GO:0042254
GO:0042255
GO:0042273
GO:0042274
GO:0042393
GO:0042802
GO:0042803
GO:0043023
GO:0043024
GO:0043066
GO:0043226
GO:0043516
GO:0044387
GO:0045727
GO:0045893
GO:0045944
GO:0046599
GO:0048025
GO:0050821
GO:0051059
GO:0051082
GO:0051092
GO:0051726
GO:0060090
GO:0060699
GO:0060735
GO:0065003
GO:0090398
GO:0098772
GO:0140110
GO:0140297
GO:0140693
GO:1902629
GO:1902751
GO:1904751
GO:1990904
HMNXSV003029586
HMNXSV003034873
HMNXSV003056309
Hs.9614.1.A1_3p_a_at
ILMN_1678775
M23613_at
PH_hs_0030093
TC01000357.hg
TC05000942.hg
g12803184_3p_a_at
g13536990_3p_s_at
Participates
Other forms of this molecule
Inferred To
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 263
Coordinate
263
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Interactors (143)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9H4L4 SENP3  1 0.78 7
 UniProt:Q96BK5 PINX1      0.757 12
 UniProt:Q86SE8 NPM2  1 0.743 8
 UniProt:O75607 NPM3      0.725 6
 UniProt:Q9BQG0 MYBBP1A  1 0.712 4
 UniProt:Q00987 MDM2  11 0.697 5
 UniProt:P04637 TP53  20 0.676 6
 UniProt:Q71RC2 LARP4      0.669 3
 UniProt:Q8IZL8 PELP1  1 0.664 4
 UniProt:P62753 RPS6  4 0.65 3
 UniProt:Q96CT7 CC124      0.649 8
 UniProt:Q9BZE4 GTPB4      0.643 4
 UniProt:Q13823 NOG2      0.643 3
 UniProt:P61313 RPL15  1 0.643 3
 UniProt:Q14690 PDCD11  1 0.643 3
 UniProt:Q14684 RRP1B      0.643 4
 UniProt:Q15397 PUM3      0.643 4
 UniProt:P46777 RPL5  1 0.643 3
 UniProt:P46781 RPS9  2 0.643 3
 UniProt:Q14137 BOP1  1 0.643 3
 UniProt:B1Q2W9 B1Q2W9      0.639 8
 UniProt:Q96GD4 AURKB  3 0.626 5
 UniProt:P24938 CORE5      0.623 4
 UniProt:Q6UPD4 Q6UPD4      0.619 4
 UniProt:P13569 CFTR  17 0.615 15
 UniProt:P19338 NCL  3 0.615 3
 UniProt:Q9BZQ8 NIBA1      0.602 7
 UniProt:P19525 EIF2AK2  5 0.602 4
 UniProt:Q9BXL5 HEMGN      0.599 7
 UniProt:P49450 CENPA  2 0.597 4
 UniProt:P68951 NP      0.591 5
 UniProt:P05549 TFAP2A  1 0.591 6
 UniProt:O00505 KPNA3  2 0.59 2
 UniProt:O14746 TERT  1 0.576 5
 UniProt:P0DOE7 M  5 0.576 3
 UniProt:P49207 RPL34  1 0.564 2
 UniProt:Q9NX58 LYAR      0.564 2
 UniProt:P63104 YWHAZ  2 0.564 2
 UniProt:Q96MT8 CEP63  1 0.564 2
 UniProt:Q8N726 CDKN2A  12 0.564 2
 UniProt:Q92876 KLK6      0.556 3
 UniProt:Q86SE8-2 NPM2      0.556 5
 UniProt:P10176 COX8A  1 0.556 3
 UniProt:P60228 EIF3E  1 0.547 2
 UniProt:P03427 PB2      0.547 3
 UniProt:P03372 ESR1  8 0.532 3
 UniProt:O76021 RL1D1      0.527 2
 UniProt:Q92522 H1X      0.527 2
 UniProt:P62424 RPL7A  1 0.527 2
 UniProt:Q6PGP7 SKIC3  1 0.527 2
 UniProt:Q9Y3C1 NOP16      0.527 3
 UniProt:P22087 FBL  1 0.527 2
 UniProt:Q07020 RPL18  1 0.527 2
 UniProt:Q9HCM4 EPB41L5  1 0.527 2
 UniProt:Q99848 EBNA1BP2  1 0.527 3
 UniProt:P39019 RPS19  2 0.527 2
 UniProt:Q15050 RRS1      0.527 3
 UniProt:O00566 MPHOSPH10  1 0.527 2
 UniProt:P63220 RPS21  2 0.527 2
 UniProt:O00567 NOP56  2 0.527 2
 UniProt:Q1ED39 KNOP1      0.527 2
 UniProt:O15381 NVL      0.527 2
 UniProt:P10636-8 MAPT  3 0.527 6
 UniProt:Q96PV0 SYNGAP1  1 0.527 2
 UniProt:Q7Z478 DHX29      0.527 2
 UniProt:Q14692 BMS1  1 0.527 2
 UniProt:Q9ULW3 ABT1      0.527 2
 UniProt:P35268 RPL22  1 0.527 2
 UniProt:Q06787 FMR1      0.527 3
 UniProt:Q12788 TBL3  1 0.527 2
 UniProt:P60866 RPS20  2 0.527 2
 UniProt:Q5JTH9 RRP12      0.527 2
 UniProt:Q9Y3B9 RRP15      0.527 2
 UniProt:O75683 SURF6      0.527 3
 UniProt:P62750 RPL23A  1 0.527 3
 UniProt:Q6P158 DHX57      0.527 2
 UniProt:O76094 SRP72  1 0.527 2
 UniProt:P05386 RPLP1  1 0.527 2
 UniProt:Q6PK04 CC137      0.527 2
 UniProt:Q8TDN6 BRX1      0.527 3
 UniProt:Q9NW13 RBM28  1 0.527 2
 UniProt:Q96GQ7 DDX27      0.527 3
 UniProt:Q9NRX1 PNO1  2 0.527 2
 UniProt:Q49A26 GLYR1      0.527 3
 UniProt:P49711 CTCF  1 0.527 2
 UniProt:Q14694 USP10  3 0.527 2
 UniProt:Q9GZL7 WDR12  1 0.527 2
 UniProt:P62861 FAU  2 0.527 2
 UniProt:Q969S3 ZN622      0.527 2
 UniProt:P36578 RPL4  1 0.527 3
 UniProt:Q14152 EIF3A  1 0.527 2
 UniProt:P42696 RBM34      0.527 3
 UniProt:P50914 RPL14  1 0.527 2
 UniProt:Q9GZR2 REXO4      0.527 3
 UniProt:P46013 KI67      0.527 2
 UniProt:O75818 RPP40  1 0.527 3
 UniProt:P19320 VCAM1  1 0.527 4
 UniProt:O95707 POP4  1 0.527 3
 UniProt:O15226 NKRF      0.527 2
 UniProt:P15880 RPS2  3 0.527 2
 UniProt:Q15477 SKIC2  1 0.527 2
 UniProt:Q9UNX4 WDR3  1 0.527 2
 UniProt:P62906 RPL10A  1 0.527 2
 UniProt:P35251 RFC1  1 0.527 2
 UniProt:Q96HI0 SENP5  1 0.527 3
 UniProt:Q8TDD1 DDX54      0.527 3
 UniProt:P46783 RPS10  2 0.527 2
 UniProt:P46782 RPS5  2 0.527 2
 UniProt:Q9P287 BCCIP      0.527 2
 UniProt:P62857 RPS28  2 0.527 2
 UniProt:O60264 SMARCA5  1 0.527 2
 UniProt:Q9BYG3 MK67I      0.527 2
 UniProt:Q9H7B2 RPF2      0.527 2
 UniProt:P61513 RPL37A  1 0.527 2
 UniProt:Q99613 EIF3C  1 0.527 2
 UniProt:Q13283 G3BP1  1 0.527 2
 UniProt:P62280 RPS11  2 0.527 2
 UniProt:Q99575 POP1  1 0.527 2
 UniProt:Q9BQ39 DDX50      0.527 2
 UniProt:Q9NXF1 TEX10  1 0.527 3
 UniProt:P78346 RPP30  1 0.527 2
 UniProt:Q7KZF4 SND1  2 0.527 2
 UniProt:Q9Y4W2 LAS1L  1 0.527 2
 UniProt:Q6NW34 NEPRO      0.527 3
 UniProt:Q9H6F5 CCD86      0.527 2
 UniProt:Q6DKI1 RL7L      0.527 3
 UniProt:P62263 RPS14  2 0.527 2
 UniProt:Q01780 EXOSC10  1 0.527 2
 UniProt:O43159 RRP8  1 0.527 3
 UniProt:O96028 NSD2  2 0.527 2
 UniProt:Q71UM5 RPS27L  2 0.527 2
 UniProt:P62241 RPS8  2 0.527 2
 UniProt:Q8IY81 FTSJ3  1 0.527 3
 UniProt:P40429 RPL13A  2 0.527 2
 UniProt:Q6PKG0 LARP1  1 0.527 2
 UniProt:Q13547 HDAC1  2 0.524 2
 UniProt:Q98147 Q98147      0.524 2
 UniProt:Q14684-1 RRP1B      0.512 4
 UniProt:Q10570 CPSF1  1 0.499 2
 UniProt:Q9UQ80 PA2G4  2 0.491 3
 UniProt:O14965 AURKA  6 0.489 3
 UniProt:Q8IUH3 RBM45      0.462 2
 UniProt:P11387 TOP1  2 0.462 3
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