Reactome | SUMO2,3-K263-NPM1 [nucleoplasm]

SUMO2,3-K263-NPM1 [nucleoplasm]

Stable Identifier

R-HSA-4086056

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nucleophosmin, NPM_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9BQG0

Expand all

Literature References

PubMed ID	Title	Journal	Year
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC	Nat. Struct. Mol. Biol.	2014
17535915	Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival Liu, X, Liu, Z, Jang, SW, Ma, Z, Shinmura, K, Kang, S, Dong, S, Chen, J, Fukasawa, K, Ye, K	Proc. Natl. Acad. Sci. U.S.A.	2007
19240082	Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites Blomster, HA, Hietakangas, V, Wu, J, Kouvonen, P, Hautaniemi, S, Sistonen, L	Mol. Cell Proteomics	2009

External Reference Information

External Reference

UniProt:P06748 NPM1

Gene Names

NPM1, NPM

Chain

chain:1-294

Reference Genes

BioGPS Gene:4869 NPM1

COSMIC (genes):NPM1 NPM1

CTD Gene:4869 NPM1

dbSNP Gene:4869 NPM1

ENSEMBL:ENSG00000181163 NPM1

HGNC:7910 NPM1

KEGG Gene (Homo sapiens):4869 NPM1

Monarch:4869 NPM1

NCBI Gene:4869 NPM1

OMIM:164040 NPM1

UCSC:P06748 NPM1

Reference Transcript

Other Identifiers

0000870408

11730790_x_at

11730912_at

11754066_x_at

11757362_x_at

11757386_x_at

18670158

18670159

18670165

18670166

18670167

200063_PM_s_at

200063_s_at

221691_3p_x_at

221691_x_at

221923_s_at

2326906

2666248

2840617

2840618

2840620

2840621

2840623

2840626

2840627

2840628

2840629

2840631

2840633

2840638

2840640

2840641

2840642

2840643

2840646

2840647

2840648

2867271

2867272

2867273

2867274

2867275

2867281

2867283

2960052

2960054

3100478

3100479

3136166

3404467

3404471

38542_at

4869

78344_at

7892530

7892853

7893382

7893420

7893571

7893657

7894485

7894919

7895119

7895225

7895472

7895509

7896054

8109975

8180407

8180408

8180409

88066_s_at

A_14_P116462

A_14_P127485

A_23_P214037

A_24_P188941

GE79895

GO:0000055

GO:0000056

GO:0001046

GO:0003674

GO:0003676

GO:0003677

GO:0003682

GO:0003713

GO:0003723

GO:0004860

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005925

GO:0006259

GO:0006281

GO:0006334

GO:0006338

GO:0006357

GO:0006407

GO:0006412

GO:0006464

GO:0006810

GO:0006886

GO:0006913

GO:0006950

GO:0007010

GO:0007049

GO:0007098

GO:0007165

GO:0007568

GO:0007569

GO:0008104

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0009056

GO:0009058

GO:0010824

GO:0010826

GO:0015031

GO:0016020

GO:0016032

GO:0019899

GO:0019901

GO:0022607

GO:0030234

GO:0030957

GO:0031616

GO:0032071

GO:0032991

GO:0032993

GO:0033613

GO:0034080

GO:0034641

GO:0034644

GO:0034655

GO:0042254

GO:0042255

GO:0042273

GO:0042274

GO:0042393

GO:0042803

GO:0043023

GO:0043024

GO:0043066

GO:0043226

GO:0044387

GO:0044403

GO:0045727

GO:0045893

GO:0045944

GO:0046599

GO:0051059

GO:0051082

GO:0051092

GO:0051276

GO:0060699

GO:0060735

GO:0065003

GO:1902629

GO:1902751

GO:1990904

HMNXSV003029586

HMNXSV003034873

HMNXSV003056309

Hs.9614.1.A1_3p_a_at

ILMN_1678775

M23613_at

PH_hs_0030093

TC01000357.hg

TC05000942.hg

g12803184_3p_a_at

g13536990_3p_s_at

Participates

as an output of

SUMOylation of NPM1 with SUMO2,3 (Homo sapiens)

Other forms of this molecule

NPM1 [cytosol]

p-S4-NPM1 [cytosol]

NPM1 [nucleoplasm]

SUMO1-K263-NPM1 [nucleoplasm]

Inferred To

NPM1 [nucleoplasm] (Gallus gallus)

Nlp [nucleoplasm] (Drosophila melanogaster)

Npm1 [nucleoplasm] (Mus musculus)

Npm1 [nucleoplasm] (Rattus norvegicus)

npm1a [nucleoplasm] (Danio rerio)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 263

Coordinate

263

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_002511.1, NP_954654.1, NP_001032827.1

Target Pathogen

5b354852be737e166372e87a

OpenTargets

ENSG00000181163

HPA

ENSG00000181163-NPM1

GeneCards

P06748

Ensembl

ENST00000351986, ENSP00000341168, ENST00000393820, ENSP00000296930, ENST00000296930, ENST00000517671, ENSG00000181163, ENSP00000377408, ENSP00000428755

PRO

P06748

Orphanet

17401

PDB

2LLH, 5EHD, 2P1B, 2VXD

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BK5 PINX1			0.757	12
UniProt:Q9H4L4 SENP3	1	SENP3 [nucleoplasm] (R-HSA-2984296)	0.718	6
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.697	5
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.676	6
UniProt:Q86SE8 NPM2			0.666	6
UniProt:P62753 RPS6	3	p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [nucleoplasm] (R-HSA-6790606) RPS6 [cytosol] (R-HSA-72381)	0.65	3
UniProt:B1Q2W9 B1Q2W9			0.639	8
UniProt:Q96GD4 AURKB	3	AURKB [nucleoplasm] (R-HSA-4655360) SUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [cytosol] (R-HSA-174231)	0.626	5
UniProt:P24938 CORE5			0.623	4
UniProt:Q6UPD4 Q6UPD4			0.619	4
UniProt:Q9BZQ8 NIBA1			0.602	7
UniProt:Q9BXL5 HEMGN			0.599	7
UniProt:P49450 CENPA	2	CENPA [cytosol] (R-HSA-375317) CENPA [nucleoplasm] (R-HSA-606322)	0.597	4
UniProt:P05549 TFAP2A	1	TFAP2A [nucleoplasm] (R-HSA-8864280)	0.591	6
UniProt:P68951 NP			0.591	5
UniProt:P0DOE7 MATRX			0.576	3
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.576	5
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:Q71RC2 LARP4			0.564	2
UniProt:Q8N726 CDKN2A	12	p14ARF [cytosol] (R-HSA-9645669) p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF R21RfsTER47 [cytosol] (R-HSA-9646285)	0.564	2
UniProt:P10176 COX8A	1	COX8A [mitochondrial inner membrane] (R-HSA-164313)	0.556	3
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:Q86SE8-2 NPM2			0.556	5
UniProt:P60228 EIF3E	1	EIF3E [cytosol] (R-HSA-72552)	0.547	2
UniProt:P03427 PB2			0.547	3
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.532	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q14684 RRP1B			0.527	3
UniProt:O75607 NPM3			0.527	2
UniProt:Q98147 Q98147			0.524	2
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.524	2
UniProt:Q14684-1 RRP1B			0.512	4
UniProt:Q10570 CPSF1	1	CPSF1 [nucleoplasm] (R-HSA-71989)	0.499	2
UniProt:Q9UQ80 PA2G4	2	PA2G4 [azurophil granule lumen] (R-HSA-6799205) PA2G4 [extracellular region] (R-HSA-6806200)	0.491	3
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.491	2
UniProt:O14965 AURKA	6	p-T288-AURKA [nucleoplasm] (R-HSA-6805089) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.489	3
UniProt:P19525 EIF2AK2	1	EIF2AK2 [cytosol] (R-HSA-168699)	0.463	3
UniProt:P11387 TOP1	2	SUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.462	3

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