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monoSUMO1-SIN3A [nucleoplasm]
Stable Identifier
R-HSA-4086071
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SIN3A_HUMAN, Paired amphipathic helix protein Sin3a
Icon
Locations in the PathwayBrowser for interactor UniProt:O75182 SIN3B
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
TOPORS SUMOylates SIN3A with SUMO1 (Homo sapiens)
monoSUMO1-SIN3A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96ST3 SIN3A
Gene Names
SIN3A
Chain
chain:1-1273
Reference Genes
BioGPS Gene:25942 SIN3A
COSMIC (genes):SIN3A SIN3A
CTD Gene:25942 SIN3A
dbSNP Gene:25942 SIN3A
ENSEMBL:ENSG00000169375 SIN3A
HGNC:19353 SIN3A
KEGG:hsa:25942 SIN3A
Monarch:25942 SIN3A
NCBI Gene:25942 SIN3A
OMIM:607776 SIN3A
UCSC:Q96ST3 SIN3A
Reference Transcript
RefSeq:XM_006720467.3 SIN3A
RefSeq:XM_006720466.3 SIN3A
RefSeq:NM_001145357.1 SIN3A
RefSeq:XM_006720465.3 SIN3A
RefSeq:NM_015477.2 SIN3A
RefSeq:NM_001145358.1 SIN3A
Other Identifiers
11730293_a_at
11730294_a_at
11735494_a_at
16811791
17121228
225135_PM_at
225135_at
238005_PM_s_at
238005_s_at
238006_PM_at
238006_at
25942
3633311
3633397
3633398
3633399
3633400
3633401
3633402
3633404
3633405
3633406
3633407
3633408
3633409
3633411
3633412
3633413
3633414
3633415
3633417
3633418
3633419
3633422
3633424
3633425
3633426
3633427
3633429
3633430
3633431
3633432
3633433
3633434
3633435
3633436
3633437
3633438
3633439
3633440
3633441
3633442
3633443
3633444
3633445
3633446
3633447
3633448
3633450
3633451
3633452
3633459
3633462
3633463
3638857
43176_at
48171_r_at
49525_i_at
49527_r_at
69518_at
7990487
82996_at
A_23_P367676
A_24_P304760
GE56490
GE769628
GO:0000118
GO:0000122
GO:0000776
GO:0000785
GO:0001701
GO:0002218
GO:0002230
GO:0002244
GO:0002376
GO:0003677
GO:0003682
GO:0003714
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005730
GO:0006260
GO:0006325
GO:0006355
GO:0008104
GO:0010817
GO:0010971
GO:0017053
GO:0021895
GO:0030154
GO:0030336
GO:0030512
GO:0030516
GO:0031507
GO:0032991
GO:0042754
GO:0043066
GO:0043226
GO:0044877
GO:0045666
GO:0045892
GO:0048511
GO:0048856
GO:0051595
GO:0060090
GO:0060337
GO:0061629
GO:0070822
GO:0071333
GO:0072736
GO:0098772
GO:0140110
GO:0140416
GO:1900181
GO:1902455
GO:1902459
GO:1903351
HMNXSV003008289
Hs.22583.0.S1_3p_at
Hs.87327.1.S1_3p_at
ILMN_1805996
PH_hs_0001974
TC15001666.hg
Participates
as an output of
TOPORS SUMOylates SIN3A with SUMO1 (Homo sapiens)
Other forms of this molecule
SIN3A [nucleoplasm]
Inferred To
Sin3a [nucleoplasm]
(Mus musculus)
Sin3a [nucleoplasm]
(Rattus norvegicus)
SIN3 [nucleoplasm]
(Saccharomyces cerevisiae)
monoSUMO1-SIN3A [nucleoplasm]
(Dictyostelium discoideum)
sin3aa [nucleoplasm]
(Danio rerio)
SIN3A [nucleoplasm]
(Bos taurus)
SIN3A [nucleoplasm]
(Gallus gallus)
SIN3A [nucleoplasm]
(Sus scrofa)
pst1 [nucleoplasm]
(Schizosaccharomyces pombe)
sin3a [nucleoplasm]
(Xenopus tropicalis)
sin-3 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at unknown position
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
XP_006720528.1
,
XP_006720529.1
,
XP_006720530.1
,
NP_001138829.1
,
NP_056292.1
,
NP_001138830.1
OpenTargets
ENSG00000169375
ENSEMBL
ENSP00000353622
,
ENST00000564778
,
ENSP00000378402
,
ENSP00000378403
,
ENST00000360439
,
ENSP00000515834
,
ENST00000394947
,
ENST00000704312
,
ENSP00000454296
,
ENST00000394949
,
ENSP00000455204
,
ENST00000565264
HPA
ENSG00000169375-SIN3A
PRO
Q96ST3
Pharos - Targets
Q96ST3
GlyGen
Q96ST3
Orphanet
SIN3A
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.918
13
UniProt:Q92769 HDAC2
2
HDAC2 [nucleoplasm]
(R-HSA-205135)
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
0.878
7
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.725
6
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.725
6
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.675
4
UniProt:Q9H160 ING2
2
monoSUMO1-K195-ING2 [nucleoplasm]
(R-HSA-4086075)
ING2 [nucleoplasm]
(R-HSA-3215167)
0.669
4
UniProt:Q8IV20 LACC1
0.643
5
UniProt:O75446 SAP30
1
SAP30 [nucleoplasm]
(R-HSA-351693)
0.643
4
UniProt:P12755 SKI
1
SKI [nucleoplasm]
(R-HSA-173473)
0.641
3
UniProt:P51610 HCFC1
2
K48polyUb,K63polyUb-HCFC1 [nucleoplasm]
(R-HSA-5690821)
HCFC1 [nucleoplasm]
(R-HSA-1592209)
0.605
6
UniProt:Q9UQ80 PA2G4
2
PA2G4 [extracellular region]
(R-HSA-6806200)
PA2G4 [azurophil granule lumen]
(R-HSA-6799205)
0.602
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.589
2
UniProt:Q9UJV9 DDX41
4
DDX41 [nucleoplasm]
(R-HSA-9769601)
DDX41 [cytosol]
(R-HSA-3134807)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134942)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134941)
0.527
2
UniProt:Q6ZNC4 ZNF704
1
ZNF704 [nucleoplasm]
(R-HSA-2454141)
0.527
3
UniProt:Q05195 MAD1
0.527
2
UniProt:Q9H7L9 SUDS3
2
K63polyUb-SUDS3 [nucleoplasm]
(R-HSA-6782790)
SUDS3 [nucleoplasm]
(R-HSA-351696)
0.527
2
UniProt:Q9NP50 SHCAF
0.527
3
UniProt:O75182 SIN3B
1
SIN3B [nucleoplasm]
(R-HSA-3006450)
0.527
2
UniProt:Q8N344 MIER2
0.527
2
UniProt:P61244 MAX
1
MAX [nucleoplasm]
(R-HSA-3006627)
0.527
2
UniProt:P19784 CSNK2A2
2
CSNK2A2 [cytosol]
(R-HSA-201721)
CSNK2A2 [nucleoplasm]
(R-HSA-6805065)
0.527
2
UniProt:Q9BUL5 PHF23
0.527
2
UniProt:P68400 CSNK2A1
2
CSNK2A1 [cytosol]
(R-HSA-201713)
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
0.527
2
UniProt:P23246 SFPQ
3
SFPQ [nucleoplasm]
(R-HSA-3900138)
p-Y-SFPQ [nucleoplasm]
(R-HSA-8849461)
SFPQ [cytosol]
(R-HSA-9635505)
0.524
2
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.499
3
UniProt:P51608 MECP2
0.499
2
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.462
2
UniProt:Q1EHW4 SAP25
0.462
2
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