Reactome | YY1 [nucleoplasm]

YY1 [nucleoplasm]

Stable Identifier

R-HSA-4086091

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcriptional repressor protein YY1, TYY1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P49407

Expand all

External Reference Information

External Reference

UniProt:P25490 YY1

Gene Names

YY1, INO80S

Chain

chain:1-414

Reference Genes

BioGPS Gene:7528 YY1

COSMIC (genes):YY1 YY1

CTD Gene:7528 YY1

dbSNP Gene:7528 YY1

ENSEMBL:ENSG00000100811 YY1

HGNC:12856 YY1

KEGG Gene (Homo sapiens):7528 YY1

Monarch:7528 YY1

NCBI Gene:7528 YY1

OMIM:600013 YY1

UCSC:P25490 YY1

Reference Transcript

RefSeq:NM_003403.4 YY1

Other Identifiers

0001450575

11724730_at

11724731_a_at

11758914_at

11758915_a_at

11758916_at

11764091_x_at

16788384

18671130

18671132

18671134

18671136

18671137

200047_PM_s_at

200047_s_at

201901_s_at

201902_3p_s_at

201902_s_at

224711_at

224718_at

33209_at

3551689

3551690

3551691

3551692

3551693

3551694

3551695

3551706

3551718

3551721

3551723

3551724

3551725

3551726

3551727

3551728

44692_at

48339_at

7528

7893039

7893500

7893926

7893941

7893981

7894375

7894581

7894683

7894791

7894846

7895879

7896352

7896490

7896493

7976744

891_at

A_14_P133736

A_24_P219140

A_24_P916288

A_33_P3315600

GE58300

GE85965

GO:0000003

GO:0000122

GO:0000228

GO:0000400

GO:0000724

GO:0000790

GO:0000976

GO:0000978

GO:0000987

GO:0001217

GO:0001227

GO:0003674

GO:0003676

GO:0003677

GO:0003700

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0006259

GO:0006281

GO:0006310

GO:0006355

GO:0006357

GO:0006403

GO:0006464

GO:0006950

GO:0006974

GO:0007283

GO:0008150

GO:0009058

GO:0009952

GO:0010225

GO:0010628

GO:0010629

GO:0016363

GO:0016579

GO:0030154

GO:0031011

GO:0031519

GO:0032688

GO:0032991

GO:0034641

GO:0034644

GO:0034696

GO:0040007

GO:0043167

GO:0043226

GO:0043565

GO:0045944

GO:0046332

GO:0046872

GO:0048593

GO:0048856

GO:0051276

GO:0061052

GO:0071347

GO:1902894

GO:1990837

Hs.296322.0.S2_3p_at

Hs.296322.0.S3_3p_at

Hs.97496.0.S1_3p_a_at

Hs.97496.0.S3_3p_s_at

ILMN_1770892

ILMN_2181540

M77698_at

PH_hs_0024486

TC14000632.hg

TC14001851.hg

TC14001852.hg

TC14001853.hg

g6042207_3p_a_at

Participant Of

hasComponent

input

TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers bind the ERBB2 gene promoter and recruit YY1

output

FOXA1 and GATA3 bind to CCND1 promoter

Inferred To

YY2 [nucleoplasm] (Gallus gallus)

Yy1 [nucleoplasm] (Mus musculus)

Yy1 [nucleoplasm] (Rattus norvegicus)

yy1a [nucleoplasm] (Danio rerio)

NRG1 [nucleoplasm] (Saccharomyces cerevisiae)

pho [nucleoplasm] (Drosophila melanogaster)

megf11 [nucleoplasm] (Xenopus tropicalis)

YY1 [nucleoplasm] (Bos taurus)

YY1 [nucleoplasm] (Canis familiaris)

YY1 [nucleoplasm] (Sus scrofa)

Ghost homologue of YY1 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of YY1 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of YY1 [nucleoplasm] (Schizosaccharomyces pombe)

ztf-17 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003394.1

OpenTargets

ENSG00000100811

HPA

ENSG00000100811-YY1

GeneCards

P25490

Ensembl

ENST00000262238, ENSG00000100811, ENSP00000262238

PRO

P25490

Orphanet

25043

PDB

1ZNM, 1UBD, 4C5I

Interactors (61)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NBZ0 INO80E	1	INO80E [nucleoplasm] (R-HSA-5689552)	0.788	6
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.757	7
UniProt:Q9ULG1 INO80	1	INO80 [nucleoplasm] (R-HSA-5688910)	0.757	7
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.757	6
UniProt:O96019 ACTL6A	1	ACTL6A [nucleoplasm] (R-HSA-2980912)	0.718	6
UniProt:P28799 GRN	2	GRN [extracellular region] (R-HSA-6806217) GRN [azurophil granule lumen] (R-HSA-6799168)	0.666	4
UniProt:Q9H981 ACTR8	1	ACTR8 [nucleoplasm] (R-HSA-5689565)	0.643	3
UniProt:Q9H9F9 ACTR5	1	ACTR5 [nucleoplasm] (R-HSA-5688913)	0.643	3
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.643	3
UniProt:Q9H869 YYAP1			0.632	5
UniProt:Q8JSK4 Q8JSK4			0.616	4
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.602	4
UniProt:Q8IY57 YAF2	1	YAF2 [nucleoplasm] (R-HSA-8937973)	0.593	4
UniProt:Q9H869-2 YY1AP1			0.581	4
UniProt:P03259 E1A			0.581	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.556	5
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:Q9BYR2 KRTAP4-5	1	KRTAP4-5 [cytosol] (R-HSA-6809950)	0.556	3
UniProt:Q9HD64 XAGE1			0.556	3
UniProt:Q8IWZ5 TRI42			0.556	3
UniProt:Q969G2 LHX4	1	LHX4 [nucleoplasm] (R-HSA-9010585)	0.556	3
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
UniProt:P60328 KRTAP12-3	1	KRTAP12-3 [cytosol] (R-HSA-6810284)	0.556	3
UniProt:Q9BYR9 KRTAP2-4	1	KRTAP2-4 [cytosol] (R-HSA-6809951)	0.556	3
UniProt:Q9UBR4-2 LHX3			0.556	3
UniProt:Q96IK5 GMCL1			0.556	5
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:Q9BYS1 KRTAP1-5	1	KRTAP1-5 [cytosol] (R-HSA-6809867)	0.556	3
UniProt:Q9NQ30 ESM1			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
IntAct:EBI-22310722 CCSB ORF ID			0.556	3
UniProt:P59991 KRTAP12-2	1	KRTAP12-2 [cytosol] (R-HSA-6810271)	0.556	3
UniProt:Q49A12 Q49A12			0.556	3
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.556	3
UniProt:P22301 IL10	1	IL10 [extracellular region] (R-HSA-447125)	0.556	3
UniProt:Q9BYP8 KRTAP17-1	1	KRTAP17-1 [cytosol] (R-HSA-6809980)	0.556	3
UniProt:P28799-2 GRN			0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128fs3 [cytosol] (R-HSA-3642173) TGFBR2 K128fs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q6L8G9 KRTAP5-6	1	KRTAP5-6 [cytosol] (R-HSA-6810276)	0.556	3
UniProt:Q2TAL6 VWC2			0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:P60370 KRTAP10-5	1	KRTAP10-5 [cytosol] (R-HSA-6810260)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q9BYQ0 KRTAP9-8	1	KRTAP9-8 [cytosol] (R-HSA-6809953)	0.556	5
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.556	5
UniProt:Q9BYQ3 KRTAP9-3	1	KRTAP9-3 [cytosol] (R-HSA-6809954)	0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
UniProt:P45973 CBX5	2	SUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849) CBX5 [nucleoplasm] (R-HSA-994093)	0.556	3
UniProt:O15354 GPR37	1	GPR37 [plasma membrane] (R-HSA-5333623)	0.556	3
UniProt:Q9BYJ1 ALOXE3	1	ALOXE3 [cytosol] (R-HSA-8942204)	0.556	3
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.556	3
UniProt:Q8CCI5	1	Rybp [nucleoplasm] (R-MMU-8937975)	0.544	2
UniProt:Q6P4R8 NFRKB	1	NFRKB [nucleoplasm] (R-HSA-5689578)	0.527	2
UniProt:P0C1Z6 TFPT	1	TFPT [nucleoplasm] (R-HSA-5689542)	0.527	2
UniProt:Q53TQ3 INO80D	1	INO80D [nucleoplasm] (R-HSA-5689559)	0.527	2
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.527	2
UniProt:P78527 PRKDC	4	PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766)	0.499	2

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