Reactome: A Curated Pathway Database

IBSP binds collagen type I

Stable Identifier
R-HSA-4086204
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Bone sialoprotein 2 binds collagen type I
Locations in the PathwayBrowser
Summation

Bone sialoprotein 2 (IBSP) is an anionic phosphorylated glycoprotein expressed almost exclusively in mineralized tissues. It is a potent nucleator of hydroxyapatite formation. The binding of IBSP to collagen is thought to be important for the initiation of bone mineralization and in the adhesion of bone cells to the mineralized matrix (Fujisawa et al. 1995, Tye et al. 2005).

Participants
Participant Of
Inferred From