OPN (osteopontin) degradation by MMP3, MMP7

Stable Identifier
R-HSA-4086205
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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OPN is a substrate for MMP3 and MMP7. Three cleavage sites were identified, Gly166-Leu167, Ala201-Tyr202 (MMP-3 only), and Asp210-Leu211. The resulting OPN fragments facilitate adhesion and migration in vitro through activation of beta1-containing integrins (Agnihotri et al. 2001). OPN has also been shown to be a substrate for liver transglutaminase and plasma transglutaminase factor IIIa, resulting in protein crosslinking (Prince et al. 1991), enhanced cell adhesion, spreading, focal contact formation and migration

Literature References
PubMed ID Title Journal Year
11375993 Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin)

Agnihotri, R, Crawford, HC, Haro, H, Matrisian, LM, Havrda, MC, Liaw, L

J. Biol. Chem. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of MMP3, MMP7 [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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