PLK1 phosphorylates FOXM1

Stable Identifier
R-HSA-4088134
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PLK1 phosphorylates FOXM1 on serine residues S730 and S739 (S715 and S724 in FOXM1B isoform) in the C-terminal transactivation domain (TAD). PLK1-mediated phosphorylation of FOXM1 upregulates FOXM1 transcriptional activity and is crucial for FOXM1 function at G2/M transition (Fu et al. 2008).
Literature References
PubMed ID Title Journal Year
19160488 Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

Fu, Z, van Deursen, JM, Li, H, Chen, J, Huang, J, Tindall, DJ, Malureanu, L, Wang, W

Nat. Cell Biol. 2008
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T611-FOXM1:p-T210-PLK1 [nucleoplasm]

Orthologous Events
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