PP2A-PPP2R2A dephosphorylates FOXM1

Stable Identifier
R-HSA-4088141
Type
Reaction
Species
Homo sapiens
Compartment
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FOXM1 can bind the regulatory subunit B55-alpha (PPP2R2A) of serine/threonine-protein phosphatase 2A (PP2A). PP2A dephosphorylates FOXM1, preventing its premature activation (Alvarez-Fernandez et al. 2011).

Literature References
PubMed ID Title Journal Year
21813648 Protein phosphatase 2A (B55?) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation

Alvarez-Fernández, M, Halim, VA, Aprelia, M, Laoukili, J, Mohammed, S, Medema, RH

J. Biol. Chem. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PP2A-PPP2R2A [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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