Tetrastatin binds integrin alphaVbeta3

Stable Identifier
R-HSA-4088218
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Tetrastatin, the non-collagenous C-terminal domain of collagen alpha-4(IV) has anti-tumor activity in a human melanoma model, decreasing proliferative and invasive properties of melanoma cells. This effect is mediated by integrin alphaVBeta3.

Literature References
PubMed ID Title Journal Year
22539938 Tetrastatin, the NC1 domain of the ?4(IV) collagen chain: a novel potent anti-tumor matrikine

Brassart-Pasco, S, Sénéchal, K, Thevenard, J, Ramont, L, Devy, J, Di Stefano, L, Dupont-Deshorgue, A, Brézillon, S, Feru, J, Jazeron, JF, Diebold, MD, Ricard-Blum, S, Maquart, FX, Monboisse, JC

PLoS ONE 2012
Participants
Participant Of
Orthologous Events
Authored
Reviewed