Tetrastatin binds integrin alphaVbeta3

Stable Identifier
R-HSA-4088218
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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Tetrastatin binds integrin alphaVbeta3
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Tetrastatin, the non-collagenous C-terminal domain of collagen alpha-4(IV) has anti-tumor activity in a human melanoma model, decreasing proliferative and invasive properties of melanoma cells. This effect is mediated by integrin alphaVBeta3.
Literature References
PubMed ID Title Journal Year
22539938 Tetrastatin, the NC1 domain of the ?4(IV) collagen chain: a novel potent anti-tumor matrikine

Brézillon, S, Di Stefano, L, Thevenard, J, Sénéchal, K, Devy, J, Jazeron, JF, Monboisse, JC, Brassart-Pasco, S, Feru, J, Ramont, L, Dupont-Deshorgue, A, Maquart, FX, Diebold, MD, Ricard-Blum, S

PLoS ONE 2012
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Orthologous Events
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Tetrastatin binds integrin alphaVbeta3 (Xenopus tropicalis)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2013-08-12)
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