Tetrastatin binds integrin alphaVbeta3

Stable Identifier
R-HSA-4088218
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Tetrastatin, the non-collagenous C-terminal domain of collagen alpha-4(IV) has anti-tumor activity in a human melanoma model, decreasing proliferative and invasive properties of melanoma cells. This effect is mediated by integrin alphaVBeta3.

Literature References
Participants
Participant Of
Orthologous Events
Authored
Reviewed