Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1

Stable Identifier
R-HSA-4088264
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Endostatin binds to the integrins alphaVbeta3, alphaVbeta5, alpha5beta1 (Rehn et al. 2001, Faye et al. 2009) and alpha3beta1 (Su et al. 2012). Endostatin is the cleaved non-collagenous C ternminal domain of collagen alpha-1(XVIII) a member of the multiplexin family. It inhibits endothelial cell migration, proliferation, and angiogenesis (Fu et al. 2009).

Participants
Participant Of
Orthologous Events