Reactome | monoSUMO1-K32-HIPK2 [nucleoplasm]

monoSUMO1-K32-HIPK2 [nucleoplasm]

Stable Identifier

R-HSA-4090405

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Homeodomain-interacting protein kinase 2

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General

Hoffmann et al. 2005 (205) and Gresko et al. (2005) cite lysine-25 as the SUMO-modified residue, however the motif in their papers indicates lysine-32 of the UniProt sequence is the lysine residue modified.

Literature References

PubMed ID	Title	Journal	Year
15766567	Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability Möller, A, Roscic, A, Gresko, E, Schmitz, ML	Biochem. Biophys. Res. Commun.	2005
15958389	Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification Stollberg, N, Hay, RT, Hofmann, TG, Jaffray, E, Will, H	J. Biol. Chem.	2005

External Reference Information

External Reference

UniProt:Q9H2X6 HIPK2

Gene Names

HIPK2

Chain

chain:1-1198

Reference Genes

BioGPS Gene:28996 HIPK2

COSMIC (genes):HIPK2 HIPK2

CTD Gene:28996 HIPK2

dbSNP Gene:28996 HIPK2

ENSEMBL:ENSG00000064393 HIPK2

ENSEMBL:ENSG00000064393.16 HIPK2

HGNC:14402 HIPK2

KEGG Gene (Homo sapiens):28996 HIPK2

Monarch:28996 HIPK2

NCBI Gene:28996 HIPK2

OMIM:606868 HIPK2

UCSC:Q9H2X6 HIPK2

Reference Transcript

Other Identifiers

11719404_a_at

11719405_a_at

11719406_a_at

11719407_a_at

11719408_a_at

11719409_a_at

11719410_s_at

11752111_a_at

17063461

213763_PM_at

213763_at

219028_PM_at

219028_at

224066_PM_s_at

224066_s_at

225097_PM_at

225097_at

225115_PM_at

225115_at

225116_PM_at

225116_at

225368_PM_at

225368_at

2404878

28996

3075777

3075779

3075780

3075781

3075782

3075783

3075784

3075785

3075786

3075787

3075788

3075789

3075796

3075798

3075799

3075800

3075802

3075804

3075805

3075810

3075812

3075814

3075816

3075817

3075818

3075849

3075868

3075869

37851_at

44036_at

55913_at

56287_at

72576_at

80844_at

8143307

85541_at

A_19_P00315668

A_19_P00321851

A_23_P169756

A_23_P169766

A_24_P500621

A_24_P681011

A_33_P3223121

GE537256

GE54515

GE58192

GO:0000122

GO:0000166

GO:0001654

GO:0001934

GO:0002376

GO:0003713

GO:0003714

GO:0003824

GO:0004672

GO:0004674

GO:0004713

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0006351

GO:0006355

GO:0006468

GO:0006915

GO:0006974

GO:0006978

GO:0007179

GO:0007224

GO:0007628

GO:0008283

GO:0008284

GO:0008344

GO:0009952

GO:0010494

GO:0010842

GO:0012501

GO:0016301

GO:0016310

GO:0016604

GO:0016605

GO:0016740

GO:0018105

GO:0018107

GO:0023052

GO:0030154

GO:0030163

GO:0030182

GO:0030218

GO:0030511

GO:0030514

GO:0030578

GO:0032092

GO:0036211

GO:0042771

GO:0043226

GO:0043388

GO:0043524

GO:0045766

GO:0045893

GO:0045944

GO:0046330

GO:0046332

GO:0046790

GO:0048596

GO:0048856

GO:0050877

GO:0050882

GO:0051091

GO:0051402

GO:0051726

GO:0060059

GO:0060235

GO:0060395

GO:0061072

GO:0061629

GO:0071456

GO:0090575

GO:0097193

GO:0106310

GO:0140096

GO:0140110

GO:1901796

GO:2000059

HMNXSV003048401

Hs.13417.0.S1_3p_at

Hs.21906.0.A1_3p_at

Hs.75354.1.S1_3p_at

Hs.75354.1.S2_3p_at

Hs.75354.1.S3_3p_at

ILMN_1687440

ILMN_1719828

ILMN_1912737

PH_hs_0024580

PH_hs_0039041

TC07001915.hg

TC07003195.hg

g13430859_3p_at

g13430859_3p_x_at

Participates

as an output of

SUMOylation of HIPK2 with SUMO1 (Homo sapiens)

Other forms of this molecule

HIPK2 [nucleoplasm]

p-HIPK2 [nucleoplasm]

Inferred To

monoSUMO1-K32-HIPK2 [nucleoplasm] (Bos taurus)

monoSUMO1-K32-HIPK2 [nucleoplasm] (Caenorhabditis elegans)

monoSUMO1-K32-HIPK2 [nucleoplasm] (Danio rerio)

monoSUMO1-K32-HIPK2 [nucleoplasm] (Dictyostelium discoideum)

monoSUMO1-K32-HIPK2 [nucleoplasm] (Mus musculus)

monoSUMO1-K32-HIPK2 [nucleoplasm] (Plasmodium falciparum)

monoSUMO1-K32-HIPK2 [nucleoplasm] (Rattus norvegicus)

monoSUMO1-K32-HIPK2 [nucleoplasm] (Saccharomyces cerevisiae)

monoSUMO1-K32-HIPK2 [nucleoplasm] (Schizosaccharomyces pombe)

monoSUMO1-K32-HIPK2 [nucleoplasm] (Xenopus tropicalis)

HIPK2 [nucleoplasm] (Gallus gallus)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 32

Coordinate

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001106710.1, NP_073577.3

ZINC - World Drugs

HIPK2_HUMAN

Guide to Pharmacology - Targets

2034

OpenTargets

ENSG00000064393

ZINC - FDA approved

HIPK2_HUMAN

ZINC - Substances

HIPK2_HUMAN

ZINC - Biogenic

HIPK2_HUMAN

ZINC target

Q9H2X6

PRO

Q9H2X6

PDB

7NCF, 6P5S

ZINC - Investigational

HIPK2_HUMAN

GeneCards

Q9H2X6

HPA

ENSG00000064393-HIPK2

Ensembl

ENSP00000385571, ENST00000406875, ENSP00000413724, ENST00000428878, ENSG00000064393

Pharos - Targets

Q9H2X6

ZINC - Predictions - Purchasable

HIPK2_HUMAN

HMDB Protein

HMDBP09471

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619)	0.721	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.713	3
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.645	10
UniProt:Q01196 RUNX1	5	RUNX1 [plasma membrane] (R-HSA-5667138) p-S249,S273,S276-RUNX1 [nucleoplasm] (R-HSA-8878063) MeR206,MeR210-RUNX1 [nucleoplasm] (R-HSA-8934750) p-7Y-RUNX1 [nucleoplasm] (R-HSA-8937712) RUNX1 [nucleoplasm] (R-HSA-8865295)	0.639	4
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.62	5
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.602	4
UniProt:Q04724 TLE1	2	Ub-TLE1 [nucleoplasm] (R-HSA-3322369) TLE1 [nucleoplasm] (R-HSA-212327)	0.544	2
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.544	2

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